STMN2 Human

The STMN2 gene is located on chromosome 8 (8q21.13) in humans . The gene encodes a protein that consists of 179 amino acids . The protein shares significant amino acid sequence similarity with the phosphoprotein stathmin .

Stathmin-2 is primarily involved in the regulation of microtubule stability . When phosphorylated by MAPK8, it stabilizes microtubules and consequently controls neurite length in cortical neurons . This regulatory role is essential for neuronal growth and development . Additionally, STMN2 is thought to be involved in osteogenesis .

The protein is implicated in several biological processes, including:

• Microtubule Depolymerization: STMN2 negatively regulates microtubule polymerization and depolymerization .
• Neuronal Growth: It plays a regulatory role in neuronal growth and is involved in the development of neuron projections .
• Response to Nerve Growth Factor: STMN2 is involved in the cellular response to nerve growth factor stimulus .

Reductions in the expression of the STMN2 gene have been associated with neurological disorders such as Down’s syndrome and Alzheimer’s disease . The protein’s role in neuronal growth and microtubule dynamics makes it a potential target for therapeutic interventions in these conditions.

Recombinant human STMN2 is produced using recombinant DNA technology, which involves inserting the human STMN2 gene into a suitable expression system to produce the protein in large quantities. This recombinant protein is used in various research applications to study its function and potential therapeutic uses.

STMN2 is involved in several signaling pathways, including the Rho GTPase signaling pathway . It has been shown to interact with other proteins, such as RGS6, which further highlights its role in cellular signaling and regulation .