STMN1 Human
Stathmin-1 Human Recombinant
Cat. No.
BT3473
Source
Escherichia Coli.
Synonyms
Metablastin, Phosphoprotein p19, Oncoprotein p18, PP17, PP19, PR22, Prosolin, C1orf215, FLJ32206, MGC138869, MGC138870, STMN1, Stathmin, Leukemia-associated phosphoprotein p18, Op18, Protein Pr22, LAP18, Lag, SMN.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
Recombinant Human Stathmin-1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (1-149 a.a) and having a molecular mass of 19.4 kDa. STMN1 is fused to 20 amino acid His Tga at N-Terminus and purified by conventional chromatography techniques.
Product Specs
Introduction
Stathmin-1 (STMN1) plays a crucial role in regulating microtubule structure by promoting their disassembly and inhibiting assembly. This ubiquitous cytosolic phosphoprotein acts as an intracellular messenger, integrating regulatory signals from the cellular environment. STMN1 exhibits oncogenic properties by influencing cell cycle progression, with mutations potentially leading to uncontrolled cell proliferation. Its expression is linked to cervical carcinogenesis and tumor development, making it a significant prognostic marker for cervical cancer. Additionally, STMN1 contributes to preventing the progression of ER-positive primary breast cancer. Somatic mutations in STMN1 can disrupt cellular homeostasis, ultimately contributing to tumorigenesis.
Description
Recombinant Human Stathmin-1, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 169 amino acids (with residues 1-149 representing Stathmin-1) and possessing a molecular weight of 19.4 kDa. The protein includes a 20 amino acid His-tag fused at the N-terminus and is purified using standard chromatographic techniques.
Physical Appearance
Sterile, colorless solution.
Formulation
The STMN1 protein solution is formulated in 20mM Tris-HCl buffer at pH 8 and contains 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Minimize repeated freeze-thaw cycles.
Purity
Purity exceeds 95.0% as determined by SDS-PAGE analysis.
Synonyms
Metablastin, Phosphoprotein p19, Oncoprotein p18, PP17, PP19, PR22, Prosolin, C1orf215, FLJ32206, MGC138869, MGC138870, STMN1, Stathmin, Leukemia-associated phosphoprotein p18, Op18, Protein Pr22, LAP18, Lag, SMN.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD.
Product Science Overview
Structure and Function
Oncogenic Activity
Stathmin-1 is known to have oncogenic activity, meaning it can contribute to the development and progression of cancer . It has been implicated in the aggressive behavior of multiple epithelial malignancies. The protein’s expression levels are often elevated in various types of cancer, making it a potential biomarker for poor prognosis and sensitivity to certain chemotherapeutic agents, such as paclitaxel .
Therapeutic Potential
Recombinant Human Stathmin-1
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