STK16 Human
Serine/Threonine Kinase 16 Human Recombinant
Cat. No.
BT22393
Source
Escherichia Coli.
Synonyms
Serine/threonine-protein kinase 16, Myristoylated and palmitoylated serine/threonine-protein kinase, MPSK, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, Tyrosine-protein kinase STK16, hPSK, STK16, MPSK1, PKL12, TSF1, KRCT.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
STK16 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 329 amino acids (1-305 a.a) and having a molecular mass of 37.2kDa.
STK16 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
STK16 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Serine/threonine-protein kinase 16 (STK16) is a membrane-associated protein kinase that adds phosphate groups to serine and threonine residues. It plays a role in the movement of secretory vesicles and intracellular signaling. Additionally, STK16 might be involved in regulating how stromal and epithelial cells interact during the formation of ducts in the mammary gland. While STK16 can add a phosphate group to itself at a Tyrosine residue, it's unclear if it functions as a tyrosine-protein kinase for other proteins. STK16 may also be part of the TGF-beta signaling pathway.
Description
Recombinant human STK16, produced in E. coli, is a single polypeptide chain without any sugar modifications. It consists of 329 amino acids (specifically, amino acids 1 to 305) and has a molecular weight of 37.2 kDa. A 24-amino acid His-tag is attached to the N-terminus of STK16. The protein is purified using specialized chromatographic methods.
Physical Appearance
A clear and sterile solution.
Formulation
The STK16 protein is provided in a solution at a concentration of 1mg/ml. The solution also contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.1M NaCl, and 1mM DTT.
Stability
For short-term storage (up to 4 weeks), keep the vial at 4°C. For longer periods, store the protein at -20°C. Adding a carrier protein (like HSA or BSA) to a final concentration of 0.1% is recommended for long-term storage. Repeated freezing and thawing of the protein should be avoided.
Purity
The purity of the protein is greater than 90%, as determined by SDS-PAGE analysis.
Synonyms
Serine/threonine-protein kinase 16, Myristoylated and palmitoylated serine/threonine-protein kinase, MPSK, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, Tyrosine-protein kinase STK16, hPSK, STK16, MPSK1, PKL12, TSF1, KRCT.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMGHALC VCSRGTVIID NKRYLFIQKL GEGGFSYVDL VEGLHDGHFY ALKRILCHEQ QDREEAQREA DMHRLFNHPN ILRLVAYCLR ERGAKHEAWL LLPFFKRGTL WNEIERLKDK GNFLTEDQIL WLLLGICRGL EAIHAKGYAH RDLKPTNILL GDEGQPVLMD LGSMNQACIH VEGSRQALTL QDWAAQRCTI SYRAPELFSV QSHCVIDERT DVWSLGCVLY AMMFGEGPYD MVFQKGDSVA LAVQNQLSIP QSPRHSSALR QLLNSMMTVD PHQRPHIPLL LSQLEALQPP APGQHTTQI.
Product Science Overview
Molecular Characteristics
STK16 is a membrane-associated protein primarily localized to the Golgi apparatus . It has a molecular weight of approximately 38.7 kDa and is expressed in various tissues, including the fetal liver . The protein is involved in several cellular processes, including signal transduction pathways and transcriptional regulation .
Functional Roles
Post-Translational Modifications
Research and Applications
Recombinant human STK16 is widely used in research to study its role in various cellular processes and its potential implications in diseases. It is available in purified forms, often tagged with His-tag for easy detection and purification . Researchers utilize STK16 in kinase assays to understand its activity and interactions with other proteins .
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