STK17B Human

The STK17B gene is located on chromosome 2 and encodes a protein consisting of 372 amino acids . The protein has several key functional domains, including ATP-binding sites and an active site essential for its kinase activity . The enzyme’s catalytic activity involves transferring a phosphate group from ATP to serine or threonine residues on substrate proteins .

STK17B is primarily involved in the regulation of apoptosis, a programmed cell death process crucial for maintaining cellular homeostasis . It acts as a positive regulator of apoptosis by phosphorylating myosin light chains, which are involved in the contraction of the actin cytoskeleton . Additionally, STK17B is implicated in intracellular signal transduction and protein phosphorylation, further highlighting its role in cellular regulation .

STK17B is associated with several biological pathways, including:

• Sweet Taste Signaling
• Apoptosis and Autophagy

These pathways underscore the kinase’s involvement in both sensory perception and cellular degradation processes. Moreover, STK17B interacts with various proteins and participates in complex signaling networks that regulate cell survival and death .

Mutations or dysregulation of the STK17B gene have been linked to certain diseases, such as exudative glomerulonephritis . Understanding the function and regulation of STK17B can provide insights into the molecular mechanisms underlying these conditions and potentially lead to the development of targeted therapies.

Human recombinant STK17B is widely used in research to study its biochemical properties and role in cellular processes. Recombinant proteins are produced through genetic engineering techniques, allowing scientists to investigate the kinase’s function in vitro and in vivo. These studies contribute to our understanding of STK17B’s role in health and disease and may pave the way for novel therapeutic approaches.