SPSB1 Human

SPRY Domain-Containing SOCS Cox Protein 1, also known as SPSB1, is a human recombinant protein that plays a crucial role in various cellular processes. This protein is part of the SOCS (Suppressor of Cytokine Signaling) family, which is involved in the negative regulation of cytokine signaling pathways. The SPRY domain is a conserved protein domain that is involved in protein-protein interactions.

The human recombinant SPRY Domain-Containing SOCS Cox Protein 1 is typically produced in Escherichia coli (E. coli) and is a single, non-glycosylated polypeptide chain. It contains 231 amino acids, specifically from the 24th to the 223rd amino acid of the native protein . The molecular mass of this recombinant protein is approximately 26 kDa .

SPRY Domain-Containing SOCS Cox Protein 1 functions as a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex . This complex is involved in the ubiquitination and subsequent proteasomal degradation of target proteins. By regulating the degradation of specific proteins, SPSB1 plays a critical role in controlling various cellular processes, including signal transduction, cell cycle progression, and immune responses.

The SOCS family proteins, including SPSB1, are essential for maintaining cellular homeostasis. They act as negative regulators of cytokine signaling, preventing excessive inflammatory responses and ensuring that signaling pathways are tightly controlled. Dysregulation of SOCS proteins can lead to various diseases, including autoimmune disorders, chronic inflammation, and cancer.

Human recombinant SPRY Domain-Containing SOCS Cox Protein 1 is widely used in research to study its role in cytokine signaling and its potential therapeutic applications. It is also used in the development of assays to screen for modulators of SOCS protein activity, which could lead to new treatments for diseases associated with cytokine signaling dysregulation.