SNRPG Human

Small Nuclear Ribonucleoprotein Polypeptide G Human Recombinant
Cat. No.
BT1740
Source
Escherichia Coli.
Synonyms
Small nuclear ribonucleoprotein G, snRNP-G, Sm protein G, Sm-G, SmG, SNRPG, PBSCG, MGC117317.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

SNRPG Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 96 amino acids (1-76 a.a.) and having a molecular mass of 10.6kDa.
The SNRPG is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Small nuclear ribonucleoprotein polypeptide G (SNRPG) belongs to the snRNP Sm proteins family, encompassing at least 7 isoforms: B/B, E, F, G, D1, D2, and D3. These proteins play a crucial role in snRNP biogenesis. Human Sm G genes are located on chromosome 2. Notably, these proteins are primary targets for anti-Sm autoantibodies, which serve as diagnostic markers for systemic lupus erythematosus (SLE). A specific class of these autoantibodies exhibits reactivity towards native Sm E-F-G complexes.
Description
Recombinant human SNRPG, expressed in E. coli, is a single, non-glycosylated polypeptide chain. This protein comprises 96 amino acids (including a 20 amino acid His tag at the N-terminus, spanning residues 1-76) and has a molecular weight of 10.6 kDa. Purification of SNRPG is achieved using proprietary chromatographic methods.
Physical Appearance
Clear, colorless solution, sterile-filtered.
Formulation
SNRPG is provided as a 1 mg/ml solution in 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol, and 0.1M NaCl.
Stability
For short-term storage (up to 2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 95.0% as determined by SDS-PAGE analysis.
Synonyms
Small nuclear ribonucleoprotein G, snRNP-G, Sm protein G, Sm-G, SmG, SNRPG, PBSCG, MGC117317.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT SGQQNNIGMV VIRGNSIIML EALERV.

Product Science Overview

Function and Importance

SNRPG is involved in the splicing of U12-type introns in pre-mRNAs and is also a part of the U7 snRNP, which participates in the processing of the 3’ end of histone transcripts . The protein encoded by this gene is essential for the proper functioning of the spliceosome, a complex responsible for removing introns from pre-mRNA transcripts .

Genetic Information

The SNRPG gene is located on chromosome 2 and has several transcript variants encoding different isoforms . It is associated with various pathways, including the processing of capped intron-containing pre-mRNA and capped intronless pre-mRNA . Diseases associated with SNRPG include Cardiomyopathy, Dilated, 1Dd, and Spinal Muscular Atrophy .

Research and Applications

Human recombinant SNRPG is used in various research applications to study its role in mRNA splicing and its involvement in different genetic pathways. Understanding the function and structure of SNRPG can provide insights into the mechanisms of gene expression regulation and the development of certain diseases.

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