SFRP2 Human
Description
SFRP2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Secreted Frizzled-Related Protein 2 (SFRP2) is a member of the Secreted Frizzled-Related Protein (SFRP) family, which consists of five secreted glycoproteins: SFRP1, SFRP2, SFRP3, SFRP4, and SFRP5 . These proteins are characterized by a frizzled-like cysteine-rich domain (CRD) that enables them to bind to Wnt ligands or frizzled (FzD) receptors, making them potent regulators of Wnt signaling .
SFRP2 contains an N-terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain . The signal peptide is crucial for the secretion process of SFRP2, and it is likely absent in the mature secreted protein . SFRP2 functions as a modulator of Wnt signaling through direct interaction with Wnts, playing a role in regulating cell growth and differentiation in specific cell types .
Wnt signaling is a complex pathway that plays a crucial role in various biological processes, including cell proliferation, differentiation, and migration. SFRP2 is involved in both canonical and noncanonical Wnt signaling pathways . In the canonical pathway, SFRP2 binds to Wnt ligands, preventing them from interacting with their receptors and thereby inhibiting the pathway. In the noncanonical pathway, SFRP2 binds to FzD receptors on the surface of cells, activating downstream signaling pathways .
SFRP2 is often differentially expressed in the tumor microenvironment, both in metastatic and non-metastatic settings . It is specifically upregulated in the tumor vasculature of several types of cancer . SFRP2 binds to FzD receptors on the surface of tumor endothelial cells, activating downstream Wnt signaling and stimulating angiogenesis . Interestingly, the noncanonical Wnt/Ca2+ pathway seems to be a key player in this event . The pro-angiogenic effect of SFRP2 can be counteracted by antibodies targeting SFRP2, showing potential as an anti-angiogenic therapeutic target in cancer .
Given its role in tumor angiogenesis, SFRP2 shows great promise as a target for anti-cancer therapies . Specific tumor endothelial markers such as SFRP2 could be targeted to inhibit tumor growth and metastasis formation . Research is ongoing to develop therapeutic strategies that target SFRP2 without causing toxicity .
