SFRP2 Mouse
Sf9, Baculovirus cells.
Secreted frizzled-related protein 2, sFRP-2, sFRP2, Sfrp2, Protein SDF5, Sdf5, AI851596, sdf, SDF-5, FRP2secreted apoptosis related protein 1, Secreted apoptosis-related protein 1, SARP-1, Sarp1, SARP1.
Description
SFRP2 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 280 amino acids (25-295 a.a) and having a molecular mass of 32.1kDa.
SFRP2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Secreted frizzled-related protein 2, sFRP-2, sFRP2, Sfrp2, Protein SDF5, Sdf5, AI851596, sdf, SDF-5, FRP2secreted apoptosis related protein 1, Secreted apoptosis-related protein 1, SARP-1, Sarp1, SARP1.
Sf9, Baculovirus cells.
ADPLFLFGQP DFSYKRSNCK PIPANLQLCH GIEYQNMRLP NLLGHETMKE VLEQAGAWIP LVMKQCHPDT KKFLCSLFAP VCLDDLDETI QPCHSLCVQV KDRCAPVMSA FGFPWPDMLE CDRFPQDNDL CIPLASSDHL LPATEEAPKV CEACKTKNED DNDIMETLCK NDFALKIKVK EITYINRDTK IILETKSKTI YKLNGVSERD LKKSVLWLKD SLQCTCEEMN DINAPYLVMG QKQGGELVIT SVKRWQKGQR EFKRISRSIR KLQCHHHHHH
Product Science Overview
SFRP2 contains a signal peptide, a netrin domain (NTR), and a frizzled-like cysteine-rich domain (Fz/CRD) . The signal peptide is crucial for the secretion process of SFRP2, while the Fz/CRD domain enables it to bind to Wnt ligands or Frizzled (FzD) receptors . This binding makes SFRP2 a potent regulator of Wnt signaling, a pathway that plays a critical role in cell proliferation, differentiation, and migration .
SFRP2 acts as a soluble modulator of Wnt signaling by binding to Wnt ligands and preventing their interaction with Frizzled receptors . This inhibition prevents β-catenin from translocating from the cytoplasm to the nucleus, thereby affecting cell proliferation, survival, differentiation, and migration . Interestingly, SFRP2 is involved in both canonical and noncanonical Wnt signaling pathways .
SFRP2 has been shown to be differentially expressed in various types of cancer . It is specifically upregulated in the tumor vasculature, where it binds to FzD receptors on the surface of tumor endothelial cells, activating downstream Wnt signaling and stimulating angiogenesis . This pro-angiogenic effect can be counteracted by antibodies targeting SFRP2, making it a promising target for anti-cancer therapies .
Additionally, methylation of the SFRP2 gene is a potential marker for the presence of colorectal cancer . In mouse models, SFRP2 has been shown to play a role in the regeneration of cardiomyocytes, which may lead to new treatments for heart injury .
Research on SFRP2 continues to uncover its various roles in different biological processes and diseases. Its involvement in Wnt signaling and tumor angiogenesis highlights its potential as a therapeutic target in cancer treatment . Moreover, its role in heart regeneration opens new avenues for cardiovascular research .
