SERPINB5 Human, His
Greater than 95.0% as determined by SDS-PAGE.
Description
SERPINB5 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 395 amino acids (1-375 a.a.) and having a molecular mass of 44.2 kDa.
The SERPINB5 is purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKILVVNAAYFVGK WMKKFPESET KECPFRVNKT DTKPVQMMNM EATFCMGNID SINCKIMELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQLNSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP.
Product Science Overview
Serpin Peptidase Inhibitor, Clade B Member 5, also known as SERPINB5 or Maspin, is a member of the serine protease inhibitor (serpin) family. This family of proteins is known for its role in inhibiting serine proteases, which are enzymes that cleave peptide bonds in proteins. The recombinant form of SERPINB5, tagged with a His (histidine) tag, is used in various research applications to study its function and interactions.
The SERPINB5 gene is located on chromosome 18 and encodes a protein that is approximately 42 kDa in size. The protein consists of a single polypeptide chain and does not undergo the typical serpin conformational change from the stressed (S) to the relaxed ® state, which is characteristic of active serpins . This unique feature means that SERPINB5 does not exhibit serine protease inhibitory activity .
SERPINB5 is primarily known for its role as a tumor suppressor. It has been shown to inhibit the growth, invasion, and metastatic properties of mammary tumors . Despite lacking serine protease inhibitory activity, SERPINB5 plays a crucial role in regulating cell adhesion, motility, and apoptosis. It is involved in several biological processes, including extracellular matrix organization, prostate gland morphogenesis, and regulation of epithelial cell proliferation .
SERPINB5 has been identified as a biomarker for various cancers, including hepatocellular carcinoma and bone squamous cell carcinoma . Its expression levels are often correlated with the progression and prognosis of these cancers. Additionally, SERPINB5 is being studied for its potential therapeutic applications in cancer treatment due to its tumor-suppressing properties .
The recombinant form of SERPINB5, tagged with a His tag, is produced using recombinant DNA technology. The His tag facilitates the purification and detection of the protein in research studies. This recombinant protein is used in various assays to investigate the molecular mechanisms underlying its tumor-suppressing functions and to identify potential therapeutic targets.
