SERPINB5 Antibody

Serpin Peptidase Inhibitor Clade B Member 5, commonly known as SERPINB5 or Maspin, is a member of the serpin (serine protease inhibitor) superfamily. This family of proteins is known for its diverse functions, including inhibition of proteases, hormone transport, and regulation of various physiological processes. SERPINB5 is particularly notable for its role as a tumor suppressor.

SERPINB5 is a protein-coding gene that encodes a protein involved in the inhibition of serine proteases. Unlike many other serpins, SERPINB5 does not undergo the typical stressed (S) to relaxed ® conformational change, which means it does not exhibit serine protease inhibitory activity . Instead, it functions primarily as a tumor suppressor, blocking the growth, invasion, and metastatic properties of mammary tumors .

SERPINB5 is expressed in various tissues, including the prostate gland, where it plays a role in morphogenesis and regulation of epithelial cell proliferation . It is predominantly located in the cytoplasm and has been identified as a biomarker for hepatocellular carcinoma .

SERPINB5 has been associated with several diseases, including bone squamous cell carcinoma and giant hemangioma . Its tumor-suppressing properties make it a significant focus of research in cancer biology. The protein’s ability to inhibit tumor growth and metastasis highlights its potential as a therapeutic target.

The mouse anti-human SERPINB5 antibody is derived from the hybridization of mouse myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SERPINB5 . This antibody is used in various research applications to study the expression and function of SERPINB5 in human tissues.