S100A6 Mouse
Description
S100A6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
S100A6, a member of the S100 protein family, possesses two EF-hand calcium-binding motifs. S100 proteins are found in either the cytoplasm or nucleus of various cells and play a role in regulating cellular processes like cell cycle progression and differentiation. The S100 gene family comprises at least 13 members, clustered on chromosome 1q21.
S100A6 is believed to be involved in stimulating prolactin secretion and exocytosis. Additionally, alterations in S100A6 gene expression and chromosomal rearrangements are linked to melanoma development.
This S100A6 protein is fused to a 20 amino acid His-tag at its N-terminus and undergoes purification using proprietary chromatographic techniques.
To ensure long-term stability, consider adding a carrier protein such as 0.1% HSA or BSA. Repeated freezing and thawing should be avoided.
Product Science Overview
S100A6 contains two EF-hand calcium-binding motifs, one at the N-terminus and the other at the C-terminus. These motifs allow S100A6 to bind two calcium ions with different affinities. The binding of calcium ions induces a conformational change in the protein, exposing hydrophobic regions that facilitate interactions with target proteins .
S100A6 is expressed in various tissues and cell types, including the cytoplasm, nucleus, cell membrane, and extracellular space. Its expression is regulated by several transcription factors, such as c-Myc, P53, NF-κB, USF, and Nrf2. The expression levels of S100A6 can vary depending on the specific cell type and the physical and chemical environment .
S100A6 is involved in several biological processes, including:
- Cytoskeletal Function: S100A6 interacts with proteins such as annexins and CacyBP/SIP, playing a role in cytoskeletal organization and dynamics .
- Cell Stress Response: S100A6 is implicated in the cellular response to stress, helping cells to cope with adverse conditions .
- Cell Proliferation and Differentiation: S100A6 influences cell proliferation and differentiation, making it important for tissue development and repair .
S100A6 interacts with a variety of proteins in a calcium-dependent manner. These interactions occur in different cellular compartments:
