S100A6 Murine
Description
Product Specs
Product Science Overview
S100 Calcium Binding Protein A6, also known as calcyclin, is a member of the S100 protein family. This family consists of more than 20 low-molecular-weight calcium-binding proteins, which play crucial roles in various cellular processes . The S100A6 protein is encoded by the S100a6 gene in mice, located on chromosome 3 .
The S100a6 gene encodes a protein that contains two EF-hand calcium-binding motifs . These motifs are responsible for the protein’s ability to bind calcium ions, which is essential for its function as a calcium sensor and modulator . The protein is localized in the cytoplasm and/or nucleus of a wide range of cells .
S100A6 is expressed in various tissues and cell types, including fibroblasts, epithelial cells, and certain types of neurons . Its expression is regulated by calcium levels and other signaling pathways. The protein is involved in several cellular processes, such as cell cycle progression, differentiation, and response to stress .
S100A6 plays a role in multiple physiological processes by interacting with other proteins, such as TPR-containing proteins . Some of its key functions include:
- Calcium Signaling: S100A6 acts as a calcium sensor and modulator, contributing to cellular calcium signaling .
- Cell Motility: It is involved in the reorganization of the actin cytoskeleton, which is crucial for cell movement .
- Exocytosis: S100A6 may stimulate Ca2±dependent insulin release and prolactin secretion .
Altered expression of S100A6 has been observed in various pathological conditions, including cancers . Its expression levels often correlate with the stage and progression of these diseases, suggesting a potential role in their development. Researchers are investigating the mechanisms through which S100A6 contributes to these pathologies and its potential as a therapeutic target .
