RPL18A Human
Ribosomal Protein L18A Human Recombinant
Cat. No.
BT15928
Source
Escherichia Coli.
Synonyms
Ribosomal Protein L18a, Ribosomal Protein L18a-Like Protein, 60S Ribosomal Protein L18a, L18A, RPL18A.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTeks products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
RPL18A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (1-176) and having a molecular mass of 23.2 kDa.
RPL18A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RPL18A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Ribosomal Protein L18A (RPL18A) is a ribosomal protein that is part of the 60S subunit and belongs to the L18AE family of ribosomal proteins. Found in the cytoplasm, RPL18A is co-transcribed with the U68 snoRNA, which is located in its third intron. This protein may be involved in viral replication through interaction with the hepatitis C virus internal ribosome entry site (IRES).
Description
Recombinant Human RPL18A, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 199 amino acids (residues 1-176) with a molecular weight of 23.2 kDa. It is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution that has been sterilized by filtration.
Formulation
The RPL18A solution (1mg/ml) is supplied in 20mM Tris-HCl buffer with a pH of 8.0, 0.4M Urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 85% by SDS-PAGE analysis.
Synonyms
Ribosomal Protein L18a, Ribosomal Protein L18a-Like Protein, 60S Ribosomal Protein L18a, L18A, RPL18A.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMKASGTL REYKVVGRCL PTPKCHTPPL YRMRIFAPNH VVAKSRFWYF VSQLKKMKKS SGEIVYCGQV FEKSPLRVKN FGIWLRYDSR SGTHNMYREY RDLTTAGAVT QCYRDMGARH RARAHSIQIM KVEEIAASKC RRPAVKQFHD SKIKFPLPHR VLRRQHKPRF TTKRPNTFF.
Product Science Overview
Structure and Function
RPL18A is composed of 176 amino acids and has an approximate molecular weight of 20 kDa . It plays a significant role in the assembly and function of ribosomes, which are responsible for translating mRNA into proteins. The protein has a high binding affinity for Importin 9, a nuclear transport receptor that prevents the aggregation of RPS7 and RPL18A in the cytoplasm .
Biological Significance
RPL18A is involved in various biological processes, including:
- Protein synthesis: As a part of the ribosomal machinery, RPL18A is essential for the translation of genetic information into functional proteins.
- Viral replication: RPL18A may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES) .
- Immune response: The protein is expressed in various tissues, including lymphoid tissue and bone marrow, where it is involved in cell proliferation and the innate immune response .
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