Resistin Human, HEK
HEK293 cells.
RETN,ADSF,FIZZ3,RETN1,RSTN,XCP1,resistin precursor, Adipose tissue-specific secretory factor, ADSFMGC126609, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3, FIZZ3; FIZZ3MGC126603, found in inflammatory zone 3, HXCP1.
Greater than 95.0% as determined by SDS-PAGE.
Description
Resistin Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (19-108 a.a) containing 96 amino acids and having a molecular mass of 10.3 kDa.
Resistin is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
RETN,ADSF,FIZZ3,RETN1,RSTN,XCP1,resistin precursor, Adipose tissue-specific secretory factor, ADSFMGC126609, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3, FIZZ3; FIZZ3MGC126603, found in inflammatory zone 3, HXCP1.
HEK293 cells.
KTLCSMEEAI NERIQEVAGS LIFRAISSIG LECQSVTSRG DLATCPRGFA VTGCTCGSAC GSWDVRAETT CHCQCAGMDW TGARCCRVQP HHHHHH
Product Science Overview
Resistin is an 11 kDa or 12.5 kDa protein consisting of 94 amino acids in mice and 108 amino acids in humans . The structure of resistin includes a carboxy-terminal disulfide-rich β-sandwich “head” domain with positive electrostatic surfaces and an amino-terminal α-helical “tail” segment with negative electrostatic potential . This unique structure allows resistin to play a role in various biological processes.
Resistin has been implicated in several physiological and pathological processes:
- Metabolic Diseases: In mice, resistin is linked to insulin resistance and type 2 diabetes . In humans, it is associated with obesity, metabolic syndrome, and cardiovascular diseases .
- Inflammatory Diseases: Resistin acts as a pro-inflammatory molecule and is involved in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease .
- Infectious Diseases: Resistin has been shown to modulate immune responses and enhance the production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12) .
- Cancer: Elevated levels of resistin have been observed in various cancers, suggesting a potential role in tumor progression .
Human recombinant resistin is produced using human embryonic kidney (HEK) cells. This method ensures that the recombinant protein closely mimics the natural human resistin in terms of structure and function. The use of HEK cells for recombinant protein production is advantageous due to their ability to perform post-translational modifications, which are essential for the biological activity of resistin.
Recent studies have highlighted the potential of resistin as a therapeutic target. Its role in modulating immune responses and inflammation makes it a promising candidate for developing new treatments for metabolic and inflammatory diseases . Additionally, understanding the mechanisms by which resistin influences cancer progression could lead to novel cancer therapies .
