RELM b Mouse

RELM-β is a non-glycosylated protein consisting of 83 amino acids, with a molecular weight of approximately 8.9 kDa . It is expressed primarily in the colon and small intestine . The protein is secreted by intestinal goblet cells and its secretion is induced by Th2 cytokines in response to nematode infections .

RELM-β plays a significant role in the immune response, particularly in the context of parasitic infections. It is involved in the regulation of inflammation and has been shown to be upregulated in various inflammatory conditions . The protein’s function is closely related to its ability to form homodimers, which are essential for its biological activity .

Recombinant mouse RELM-β is typically produced in Escherichia coli and is available as a sterile filtered, lyophilized powder . The recombinant protein is often used in research to study its role in inflammation and immune response. It is important to handle the reconstituted protein with care, ensuring it is aliquoted and stored at -20°C to maintain its stability .

RELM-β is used in various research applications, including studies on inflammation, immune response, and parasitic infections. Its role in these processes makes it a valuable tool for understanding the mechanisms underlying these conditions and for developing potential therapeutic strategies .