pro-IGF2 Human

Pro-IGF2 is a precursor to the mature Insulin-like Growth Factor-2 (IGF2), which is involved in various physiological processes. IGF2 is particularly important during fetal development, where it regulates growth and differentiation of tissues . The protein functions by binding to the IGF1 receptor (IGF1R) and the insulin receptor, initiating a cascade of intracellular signaling that promotes cell growth and survival .

The expression of IGF2 is tightly regulated by genetic and epigenetic mechanisms. It is an imprinted gene, meaning it is expressed only from the allele inherited from the father . Epigenetic changes at the IGF2 locus can lead to various disorders. For instance, loss of imprinting or mutations in the IGF2 gene are linked to overgrowth syndromes like Beckwith-Wiedemann syndrome and undergrowth conditions like Silver-Russell syndrome .

Human recombinant Pro-IGF2 is produced using recombinant DNA technology. This involves inserting the human IGF2 gene into a suitable expression system, such as bacteria or yeast, which then produce the protein. The recombinant protein is then purified and used for various research and therapeutic purposes .

IGF2 has significant clinical implications due to its role in growth and development. Abnormal levels of IGF2 are associated with various cancers, including liver, breast, and colorectal cancers . Understanding the regulation and function of IGF2 can provide insights into the development of these diseases and potential therapeutic targets.