POLR2J2 Human

The primary function of POLR2J2 is to encode a subunit of RNA polymerase II, the enzyme responsible for synthesizing messenger RNA (mRNA) in eukaryotes . RNA polymerase II catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . This process is essential for the expression of genes and the production of proteins, which are vital for various cellular functions.

POLR2J2 produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA-directed RNA polymerase II polypeptide J . Most or all variants are spliced to include additional non-coding exons at the 3’ end, making them candidates for nonsense-mediated decay (NMD) . Consequently, it is not entirely clear if this locus expresses a protein or proteins in vivo .

POLR2J2 is involved in several important biological pathways, including RNA Polymerase II Transcription Initiation and Promoter Clearance and Pyrimidine metabolism . Gene Ontology (GO) annotations related to this gene include protein dimerization activity and DNA-directed 5’-3’ RNA polymerase activity .

Diseases associated with POLR2J2 include perinephritis . Understanding the function and regulation of POLR2J2 can provide insights into the molecular mechanisms underlying these conditions and potentially lead to the development of targeted therapies.

Human recombinant POLR2J2 protein is used in various research applications to study its function and interactions. Recombinant proteins are produced by cloning the gene of interest into an expression vector, which is then introduced into a host cell to produce the protein . These proteins are essential tools for studying the biochemical properties and biological functions of POLR2J2.