PEBP1 Antibody
Phosphatidylethanolamine-binding protein 1, Prostatic-binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, PEBP-1, RKIP, PEBP1, PBP, PEBP, HCNP.
Description
Product Specs
Phosphatidylethanolamine-binding protein 1, Prostatic-binding protein, HCNPpp, Neuropolypeptide h3, Raf kinase inhibitor protein, PEBP-1, RKIP, PEBP1, PBP, PEBP, HCNP.
PEBP1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT4B11AT.
Anti-human PEBP1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PEBP1 protein, 1-187 amino acids purified from E. coli.
Mouse IgG2b heavy chain and k light chain.
Product Science Overview
Phosphatidylethanolamine Binding Protein 1 (PEBP1) is a protein that plays a crucial role in various biological processes. It is known for its ability to bind phosphatidylethanolamine, a type of phospholipid found in biological membranes. PEBP1 is also referred to as Raf Kinase Inhibitor Protein (RKIP) due to its role in inhibiting the Raf/MEK/ERK signaling pathway. The mouse anti-human PEBP1 antibody is a monoclonal antibody used in research to study the expression and function of PEBP1 in human tissues.
PEBP1 is a small protein with a molecular weight of approximately 21 kDa. It has a highly conserved structure across different species, indicating its essential role in cellular functions. The protein binds to various molecules, including ATP, opioids, and phosphatidylethanolamine. It has a lower affinity for phosphatidylinositol and phosphatidylcholine .
PEBP1 functions as a serine protease inhibitor, inhibiting enzymes such as thrombin, neuropsin, and chymotrypsin. However, it does not inhibit trypsin, tissue-type plasminogen activator, and elastase . One of the critical roles of PEBP1 is to inhibit the kinase activity of RAF1 by preventing its activation and dissociating the RAF1/MEK complex. This inhibition is crucial in regulating the MAP kinase (MAPK) signaling pathway, which controls cell proliferation, differentiation, and survival .
PEBP1 is involved in various biological processes, including neural development, cancer metastasis suppression, and regulation of signaling pathways. The protein can be processed to form a smaller cleavage product known as hippocampal cholinergic neurostimulating peptide (HCNP), which is implicated in neural development . PEBP1 has been shown to modulate multiple signaling pathways, including the MAPK, NF-kappa B, and glycogen synthase kinase-3 (GSK-3) pathways .
In cancer research, PEBP1 is considered a metastasis suppressor gene. Its expression is often downregulated in metastatic tumors, and restoring its expression can inhibit cancer cell invasion and metastasis . Additionally, PEBP1 is associated with various diseases, including parotid gland adenoid cystic carcinoma and parotid gland cancer .
The mouse anti-human PEBP1 antibody is widely used in research to study the expression and function of PEBP1 in human tissues. It is utilized in various techniques, including Western blotting, immunohistochemistry, and immunofluorescence. These techniques help researchers understand the role of PEBP1 in different biological processes and its implications in diseases.
