OTOR Human, His
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Description
Product Specs
Product Science Overview
Otoraplin, also known as OTOR, is a protein encoded by the OTOR gene. It is a member of the melanoma-inhibiting activity (MIA) gene family, which includes proteins such as melanoma inhibitory activity protein 3 (MIA3). Otoraplin is a secreted cytokine that plays a significant role in various biological processes, including cartilage development and maintenance, as well as potential therapeutic applications in cancer treatment .
The OTOR gene is located on chromosome 20 and encodes the Otoraplin protein. The protein is secreted via the Golgi apparatus and is involved in several cellular functions. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness .
Otoraplin has several key functions:
- Cartilage Development: It is believed to play a role in the development and maintenance of cartilage throughout the human body. This includes early chondrogenesis of the otic capsule, which is essential for inner ear development and auditory function .
- Cancer Treatment: Otoraplin has shown potential in inhibiting melanoma by promoting “suicide gene therapy” in malignant melanoma. This means that Otoraplin encourages cancer cells to undergo apoptosis (programmed cell death), which can be an effective treatment for melanoma .
- Cell Migration: Otoraplin acts as a regulator of cell migration. At lower concentrations, it stimulates cell migration, while at higher concentrations, it inhibits cell migration .
Recombinant Otoraplin with a His tag is a form of the protein that has been genetically engineered to include a polyhistidine tag. This tag facilitates the purification and detection of the protein in laboratory settings. The His tag allows for easy binding to nickel or cobalt ions, which can be used to isolate the protein from a mixture of other proteins and cellular components .
Otoraplin’s potential applications are still being explored, but it has shown promise in several areas:
- Melanoma Treatment: As mentioned, Otoraplin’s ability to induce apoptosis in melanoma cells makes it a potential candidate for cancer therapy .
- Cartilage Repair: Its role in cartilage development suggests potential therapeutic benefits for conditions involving cartilage damage or degeneration .
- Hearing Disorders: Given its involvement in inner ear development, mutations or disruptions in the OTOR gene may be linked to hearing disorders, making it a target for further research in this area .
