NUDT9 Human
ADP-ribose pyrophosphatase mitochondrial, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase, Nucleoside diphosphate-linked moiety X motif 9, Nudix motif 9, NUDT9, NUDT10, PSEC0099, UNQ3012/PRO9771.
Description
NUDT9 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 325 amino acids (47-350 a.a.) and having a molecular mass of 36.5kDa (molecular weight on SDS-PAGE will appear higher).
NUDT9 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
ADP-ribose pyrophosphatase mitochondrial, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase, Nucleoside diphosphate-linked moiety X motif 9, Nudix motif 9, NUDT9, NUDT10, PSEC0099, UNQ3012/PRO9771.
MGSSHHHHHH SSGLVPRGSH MNTNVMSGSN GSKENSHNKA RTSPYPGSKV ERSQVPNEKV GWLVEWQDYK PVEYTAVSVL AGPRWADPQI SESNFSPKFN EKDGHVERKS KNGLYEIENG RPRNPAGRTG LVGRGLLGRW GPNHAADPII TRWKRDSSGN KIMHPVSGKH ILQFVAIKRK DCGEWAIPGG MVDPGEKISA TLKREFGEEA LNSLQKTSAE KREIEEKLHK LFSQDHLVIY KGYVDDPRNT DNAWMETEAV NYHDETGEIM DNLMLEAGDD AGKVKWVDIN DKLKLYASHS QFIKLVAEKR DAHWSEDSEA DCHAL.
Product Science Overview
Nudix Type Motif 9 is produced in Escherichia coli as a single, non-glycosylated polypeptide chain containing 325 amino acids, spanning from amino acid 47 to 350 . The molecular mass of this protein is approximately 36.5 kDa, although it may appear higher on SDS-PAGE due to its specific properties . Additionally, Nudix Type Motif 9 is often fused to a 21 amino acid His-tag at the N-terminus to facilitate purification through chromatographic techniques .
The primary function of Nudix Type Motif 9 is to act as an ADP-ribose pyrophosphatase. This enzyme catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-phosphate. ADP-ribose is a significant molecule involved in various cellular processes, including DNA repair, cell signaling, and metabolism. By regulating the levels of ADP-ribose, Nudix Type Motif 9 plays a crucial role in maintaining cellular homeostasis and preventing the accumulation of potentially harmful metabolites.
Recombinant forms of Nudix Type Motif 9 are widely used in biochemical and structural studies to understand the enzyme’s mechanism of action and its role in cellular processes. The availability of human recombinant Nudix Type Motif 9 allows researchers to study the enzyme in a controlled environment, facilitating the development of potential therapeutic interventions targeting related metabolic pathways.
