NT 4 Antibody
Description
Product Specs
Product Science Overview
Neurotrophin-4 is a protein that is encoded by the NTF4 gene in humans. It shares structural similarities with other members of the neurotrophin family, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). NT-4 binds to specific receptors on the surface of neurons, primarily the TrkB receptor (tropomyosin receptor kinase B), to exert its biological effects. Upon binding to TrkB, NT-4 activates intracellular signaling pathways that promote neuronal survival, growth, and differentiation.
NT-4 is involved in various physiological processes, including:
- Neuronal Survival: NT-4 supports the survival of sensory and sympathetic neurons during development and in adulthood.
- Neuronal Differentiation: It promotes the differentiation of neural progenitor cells into mature neurons.
- Synaptic Plasticity: NT-4 plays a role in synaptic plasticity, which is essential for learning and memory.
- Peripheral Nervous System: It is particularly important for the maintenance and function of peripheral neurons.
The Mouse Anti-Human NT-4 Antibody is a monoclonal antibody that is specifically designed to target and bind to human NT-4. Monoclonal antibodies are produced by identical immune cells that are clones of a unique parent cell and are highly specific to a particular antigen. The Mouse Anti-Human NT-4 Antibody is used in various research applications, including:
- Western Blotting: To detect NT-4 protein levels in biological samples.
- Immunohistochemistry: To visualize the distribution and localization of NT-4 in tissue sections.
- ELISA (Enzyme-Linked Immunosorbent Assay): To quantify NT-4 protein levels in various samples.
- Flow Cytometry: To analyze the expression of NT-4 on the surface of cells.
Research on NT-4 and its interactions with the TrkB receptor has significant implications for understanding and treating neurological disorders. Dysregulation of NT-4 signaling has been implicated in various conditions, including neurodegenerative diseases (such as Alzheimer’s disease), psychiatric disorders (such as depression), and peripheral neuropathies. Therapeutic strategies that target NT-4 signaling pathways are being explored to promote neuronal survival and function in these conditions.
