Myostatin Human, HEK
Description
Product Specs
Product Science Overview
Myostatin is a secreted protein that negatively regulates muscle growth by controlling the number and size of muscle fibers. It is synthesized as a precursor protein that undergoes proteolytic processing to produce a mature, biologically active form. The mature myostatin protein forms a homodimer, which is essential for its biological activity .
Myostatin exerts its effects by binding to activin type II receptors (ACTRIIA or ACTRIIB) on the surface of muscle cells. This binding activates the SMAD signaling pathway, leading to the transcription of target genes that inhibit muscle growth. Additionally, myostatin can activate the MAPK signaling pathway through TAK1-MKK6 and Ras, further contributing to its inhibitory effects on muscle development .
Recombinant human myostatin is produced using genetically modified cells, such as HEK 293 cells or E. coli. The recombinant protein is typically expressed as a lyophilized powder and is used in various research applications, including studies on muscle growth, muscle-wasting diseases, and potential therapeutic interventions .
Inhibition of myostatin has been shown to increase muscle mass in various animal models of human diseases, such as muscular dystrophy. This has led to significant interest in developing myostatin inhibitors as potential treatments for muscle-wasting conditions. Research on myostatin also extends to its role in cardiac muscle development and function, making it a target for potential therapies in heart disease .
