MOBKL3 Human

MOB1, also known as Mps One Binder kinase Activator-Like 3, is a multifunctional protein that plays a crucial role in various cellular processes. It is best known for its integrative role in regulating metazoan Hippo and NDR pathway signaling, as well as yeast Mitotic Exit Network signaling . This protein is encoded by the MOB1A gene in humans and is involved in controlling organ size and tumor growth by enhancing apoptosis .

MOB1 is a component of the Hippo signaling pathway, which is essential for regulating cell proliferation, apoptosis, and organ size. The Hippo pathway restricts growth and impacts the development and homeostasis of animal organs . MOB1 binds to upstream kinases MST1 and MST2 and downstream AGC group kinases LATS1, LATS2, NDR1, and NDR2 . This binding is crucial for the activation of these kinases, which in turn regulate various cellular processes.

The Hippo signaling pathway is a highly conserved pathway that controls organ size and tumor suppression by restricting cell proliferation and promoting apoptosis . MOB1 acts as an allosteric activator of NDR kinases and as an adaptor that contributes to the assembly of multiprotein NDR kinase activation complexes . This pathway is central to maintaining tissue growth and morphogenesis in multicellular eukaryotes.

Loss of MOB1 function can result in uncontrolled cell proliferation and cancer formation . It has been implicated in various cancers due to its role in regulating the Hippo signaling pathway. Understanding the function and regulation of MOB1 is crucial for developing potential therapeutic strategies for cancer treatment.

Research on MOB1 has expanded significantly, with studies focusing on its role in both Hippo and Hippo-like signaling pathways . The protein’s ability to modulate the output from these pathways makes it a potential target for therapeutic interventions. Recombinant human MOB1 is used in various research applications to study its function and regulation in cellular processes.