MOBKL1B Human
Description
Product Specs
Product Science Overview
MOB1, also known as Mps One Binder Kinase Activator-Like 1B, is a multifunctional protein that plays a crucial role in various cellular processes. It is a component of the Hippo signaling pathway, which is essential for regulating organ size, cell proliferation, and apoptosis. The protein encoded by the MOB1B gene is similar to the yeast Mob1 protein, which is involved in spindle pole body duplication and mitotic checkpoint regulation .
MOB1B is an activator of LATS1/2 in the Hippo signaling pathway. This pathway is pivotal for organ size control and tumor suppression by restricting cell proliferation and promoting apoptosis. The core of this pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with their regulatory protein SAV1, phosphorylate and activate LATS1/2 in complex with MOB1. This, in turn, phosphorylates and inactivates the YAP1 oncoprotein and WWTR1/TAZ, inhibiting their translocation into the nucleus to regulate genes important for cell proliferation, cell death, and cell migration .
MOB1B binds to both upstream kinases MST1 and MST2 and downstream AGC group kinases LATS1, LATS2, NDR1, and NDR2. The binding of MOB1 to MST1 and MST2 is mediated by its phosphopeptide-binding infrastructure, which matches the phosphorylation consensus of MST1 and MST2. On the other hand, the binding of MOB1 to LATS and NDR kinases is mediated by a distinct interaction surface on MOB1. By assembling both upstream and downstream kinases into a single complex, MOB1 facilitates the activation of the latter by the former through a trans-phosphorylation event .
Mutations or dysregulation of the MOB1B gene can lead to various diseases, including Warburg Micro Syndrome 1. The protein’s role in the Hippo signaling pathway makes it a critical factor in tumor suppression and organ size regulation. Loss of MOB1B function can result in uncontrolled cell proliferation and cancer formation .
