MIF Human
Description
Macrophage Inducing Factor Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 115 amino acids (1-115aa) and having a molecular mass of 12kDa. MIF human Recombinant is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine that plays a crucial role in the regulation of the immune response. Initially identified in 1966, MIF was one of the first soluble immune mediators secreted from T-cells during delayed-type hypersensitivity reactions . It exerts inhibitory effects on the random migration of macrophages, hence its name.
MIF is known for its diverse biological properties and functions. It is stored in and secreted from the pituitary gland upon endotoxemia and acts as a key regulator of innate immunity by counter-regulating glucocorticoids . MIF is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. It also plays a significant role in inflammatory responses, acting as a mediator of both acute and chronic inflammatory diseases .
MIF is overexpressed in various types of cancer, including breast cancer . It has been suggested as a molecular link between chronic inflammation and cancer. MIF promotes tumor cell proliferation, invasion, and metastasis by interacting with its receptor, CD74 . Inhibition of MIF signaling can restore anticancer immune responses in tumor microenvironments, making it a potential target for cancer therapy .
Human recombinant MIF is produced using recombinant DNA technology, which involves inserting the gene encoding MIF into a suitable expression system, such as bacteria or insect cells . This allows for the large-scale production of MIF for research and therapeutic purposes. Recombinant MIF has been used in various studies to investigate its role in immune responses, cancer, and other diseases .
