MHC Class II Antibody
Description
Product Specs
Product Science Overview
Major Histocompatibility Complex (MHC) Class II molecules play a crucial role in the immune system by presenting antigens to T-helper cells. These molecules are primarily expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The interaction between MHC Class II molecules and T-helper cells is essential for initiating and regulating immune responses.
MHC Class II molecules are heterodimeric proteins composed of two chains: alpha (α) and beta (β). These chains form a peptide-binding groove that accommodates peptides derived from extracellular proteins. The primary function of MHC Class II molecules is to present these peptides to CD4+ T-helper cells, which then activate other immune cells to respond to the pathogen.
Mouse anti-human MHC Class II antibodies are monoclonal antibodies developed in mice that specifically target human MHC Class II molecules. These antibodies are widely used in various scientific applications, including:
- Flow Cytometry: To analyze the expression of MHC Class II molecules on the surface of cells.
- Western Blot: To detect MHC Class II proteins in cell lysates.
- Immunohistochemistry: To visualize the distribution of MHC Class II molecules in tissue sections.
- Immunoprecipitation: To isolate MHC Class II molecules from cell extracts.
- ELISA: To quantify the levels of MHC Class II molecules in biological samples.
The use of mouse anti-human MHC Class II antibodies has significantly advanced our understanding of the immune system. These antibodies have been instrumental in:
- Studying Antigen Presentation: By using these antibodies, researchers can investigate how antigens are processed and presented by APCs.
- Characterizing Immune Responses: These antibodies help in characterizing the role of MHC Class II molecules in various immune responses, including autoimmune diseases, infections, and cancer.
- Developing Therapeutics: Understanding the interaction between MHC Class II molecules and T-helper cells can lead to the development of novel immunotherapies for treating diseases.
