MHC Class II, I-A Antibody
Description
Product Specs
Product Science Overview
Major Histocompatibility Complex (MHC) Class II molecules play a crucial role in the immune system by presenting extracellularly derived antigens to CD4+ T cells. This process is essential for initiating immune responses against pathogens. In mice, MHC Class II molecules are encoded by the I-A and I-E regions of the MHC complex.
MHC Class II molecules are heterodimeric proteins composed of an alpha (α) and a beta (β) chain. These chains form a peptide-binding groove that accommodates peptides of 10-30 amino acids in length. The primary function of MHC Class II molecules is to present processed antigenic peptides to CD4+ T helper cells, which in turn activate other immune cells, including B cells and macrophages.
In mice, the I-A region of the MHC Class II complex encodes the alpha and beta chains of the MHC Class II molecule. The I-A molecule is highly polymorphic, meaning there are many different alleles that can encode slightly different versions of the molecule. This polymorphism is crucial for the immune system’s ability to recognize a wide variety of antigens.
Mouse antibodies targeting MHC Class II (I-A) are valuable tools in immunological research. These antibodies can be used in various applications, including:
- Flow Cytometry: To analyze the expression of MHC Class II molecules on the surface of cells.
- Immunohistochemistry: To visualize the distribution of MHC Class II molecules in tissue sections.
- Immunoprecipitation: To isolate MHC Class II molecules from cell lysates for further analysis.
- Functional Assays: To study the role of MHC Class II molecules in antigen presentation and T cell activation.
Antibodies against MHC Class II (I-A) are used extensively in research to study immune responses, autoimmune diseases, and transplant rejection. They help in understanding how MHC Class II molecules present antigens and how this process can be modulated to develop new therapeutic strategies.
