MFAP4 Antibody

Microfibrillar-associated protein 4 (MFAP4) is a protein that plays a crucial role in the extracellular matrix (ECM). It is a member of the fibrinogen protein family and contains a fibrinogen C-terminal domain . MFAP4 is involved in cell adhesion and intercellular interactions, making it significant in various physiological and pathological processes.

MFAP4 has binding specificities for both collagen and carbohydrates . It is primarily located in elastic fibers and is highly expressed in blood vessels . The protein is believed to contribute to the structural integrity of the ECM and is involved in the formation and maintenance of elastic fibers.

Quantitative real-time PCR studies have shown that MFAP4 mRNA is highly expressed in the heart, lung, and intestine . Immunohistochemical studies have demonstrated high levels of MFAP4 protein at sites rich in elastic fibers and within blood vessels in various tissues . This localization suggests that MFAP4 plays a significant role in maintaining the elasticity and integrity of these tissues.

MFAP4 has been studied as a potential marker for cardiovascular diseases (CVD). Serum levels of MFAP4 have been found to vary in patients with different cardiovascular conditions . For instance, lower serum MFAP4 levels have been observed in patients with stable atherosclerotic disease compared to those with ST elevation myocardial infarction (STEMI) and non-STEMI . These findings indicate that MFAP4 could be a valuable biomarker for assessing the severity and progression of cardiovascular diseases.

The mouse anti human MFAP4 antibody is a monoclonal antibody derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MFAP4 protein . This antibody is used in various research applications, including enzyme-linked immunosorbent assay (ELISA) and Western blot analysis, to study the expression and function of MFAP4 in different tissues and disease conditions .

MFAP4 has been implicated in various diseases, including cardiovascular diseases and asthma . Studies using MFAP4-deficient mouse models have shown that the protein plays a role in neointima formation and asthma . These findings highlight the importance of MFAP4 in both normal physiological processes and disease pathogenesis.