LYVE1 Antibody

LYVE1 acts as a receptor for hyaluronic acid (HA), a significant component of the extracellular matrix. This receptor binds to both soluble and immobilized forms of HA . The primary function of LYVE1 is believed to be in the transport of hyaluronan within the lymphatic system. It may facilitate the uptake of HA for catabolism within lymphatic endothelial cells or transport HA into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes .

LYVE1 plays a crucial role in various physiological processes, including:

• Lymphatic Hyaluronan Transport: It is involved in the transport of hyaluronan, which is essential for maintaining tissue hydration and facilitating cell migration during processes such as inflammation and wound healing .
• Tumor Metastasis: LYVE1 may have a role in tumor metastasis by mediating the transport of HA, which can influence tumor cell migration and invasion .

LYVE1 is predominantly expressed in lymphatic endothelial cells but is also found in other tissues such as the liver blood sinusoids and embryonic blood vessels . Additionally, LYVE1 expression has been observed in a subset of macrophages, including those in the meninges of rats .

The LYVE1 receptor is widely used as a marker for lymphatic endothelial cells in research. It allows for the isolation and study of these cells in various experimental settings . The receptor’s evolutionary conservation suggests its importance in physiological processes, although its precise role is still under investigation .

The Mouse Anti-Human LYVE1 Antibody is a monoclonal antibody used in research to detect LYVE1 in human tissues. This antibody is valuable for studying the distribution and function of LYVE1 in various physiological and pathological conditions .