LMNA Rat
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, LMNA, LMN1, Renal carcinoma antigen NY-REN-32, Progerin.
Greater than 90.0% as determined by SDS-PAGE.
Description
LMNA Rat Recombinant fused with a His tag produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 614 amino acids and having a molecular mass of 68.0kDa. The LMNA is purified by proprietary chromatographic techniques.
Product Specs
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, LMNA, LMN1, Renal carcinoma antigen NY-REN-32, Progerin.
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INATGEEVAM RKLVRSLTMV EDDEDEDGDD LLHHHHGSHC SSSGDPAEYN LRSRTVLCGT CGQPADKASA SGSGAQVSSQ NCSIM
Product Science Overview
Lamin A/C belongs to the lamin family of proteins, which are intermediate filament proteins. These proteins are highly conserved across species, indicating their fundamental role in cellular biology . Lamin A and Lamin C are produced from the same gene (LMNA) through alternative splicing. They share a common structure, including a central rod domain flanked by a head and a tail domain .
During mitosis, the nuclear lamina disassembles as lamin proteins are phosphorylated. This disassembly is crucial for the breakdown of the nuclear envelope, allowing chromosome segregation . Lamin A/C is also involved in maintaining nuclear stability and regulating gene expression .
Phosphorylation of Lamin A/C at specific sites, such as Ser22, has been identified in vivo in several cell lines . This phosphorylation is part of a typical MAPK/CDK phosphorylation motif, implicating a role in the cell cycle and mitosis . The phosphorylation state of Lamin A/C can influence its function and interactions with other nuclear components.
Recombinant Lamin A/C proteins, such as those derived from rats, are used in various research applications. These recombinant proteins are valuable tools for studying the structure and function of Lamin A/C in different cellular contexts. They are also used in assays to investigate the role of Lamin A/C in diseases and to develop potential therapeutic interventions.
