KLF7 Human
Greater than 85% as determined by SDS-PAGE.
Description
Product Specs
Kruppel-Like Factor 7 (KLF7) belongs to the Kruppel-like family of transcriptional regulators. These regulators play a crucial role in cellular processes such as cell growth, specialization, and survival. KLF7 is characterized by three C2H2 zinc fingers located at its C-terminus, which enable it to bind to GC-rich DNA sequences. This protein is implicated in the development of type 2 diabetes through two main mechanisms: suppressing the production and release of hormones from pancreatic beta-cells and disrupting the secretion of adipocytokines from adipocytes.
SDS-PAGE analysis indicates a purity exceeding 85%.
Product Science Overview
KLF7 plays a crucial role in various biological processes and has been implicated in the development and progression of several diseases. It is involved in the regulation of ribosomal biogenesis and translation, particularly in breast cancer cells . KLF7 expression levels have been correlated with the aggressiveness of certain cancer subtypes, such as triple-negative breast cancer (TNBC) .
In addition to its role in cancer, KLF7 is associated with the development of the nervous system, adipose tissue, muscle tissue, and corneal epithelium . It also plays a role in the preservation of pluripotent stem cells . Genetic studies have shown that DNA polymorphisms of KLF7 are linked to obesity, type 2 diabetes mellitus (T2DM), and mental development in some populations .
Recombinant KLF7 is produced using various expression systems, such as E. coli, to create a single polypeptide chain containing the amino acid sequence of the human KLF7 protein . This recombinant protein is often fused with tags, such as a His-tag, to facilitate purification and detection . The recombinant KLF7 protein is used in research to study its molecular functions and potential therapeutic applications.
The study of KLF7 has significant implications for understanding the molecular mechanisms underlying various diseases and developing potential therapeutic strategies. For example, KLF7’s role in ribosomal biogenesis and translation in cancer cells suggests that targeting KLF7 could be a potential therapeutic approach for certain types of cancer . Additionally, understanding the genetic and epigenetic regulation of KLF7 could provide insights into the development of metabolic and neurological disorders .
In conclusion, Krüppel-Like Factor 7 (Human Recombinant) is a vital transcription factor with diverse roles in biological processes and disease development. Its study continues to provide valuable insights into the molecular mechanisms of various diseases and potential therapeutic targets.
