KLF7 Antibody
Description
Product Specs
Product Science Overview
Krueppel-like factor 7 (KLF7) is a member of the Krueppel-like factor family of transcription factors. These factors are characterized by their zinc finger domains, which enable them to bind to DNA and regulate gene expression. KLF7 is particularly significant in the nervous system, where it plays a crucial role in regulating cell proliferation, differentiation, and survival.
KLF7 has been identified as a key regulator in the development and function of the nervous system. It influences the growth and differentiation of neurons, as well as the formation of neural networks. Research has shown that KLF7 is involved in the regeneration of injured neurons, making it a potential target for therapeutic interventions in neurodegenerative diseases and nerve injuries .
Recent studies have highlighted the role of KLF7 in autism spectrum disorder (ASD). Mutations or deficiencies in KLF7 have been linked to the development of ASD-like behaviors in animal models. For instance, KLF7 deficiency in mice has been shown to cause disruptions in circadian rhythm genes, leading to autistic-like behaviors . These findings suggest that KLF7 is a critical gene in the regulation of circadian rhythms and may contribute to the pathogenesis of ASD.
The mouse anti-human KLF7 antibody is a monoclonal antibody developed to specifically target and bind to the human KLF7 protein. This antibody is produced by immunizing mice with a recombinant human KLF7 protein, followed by the fusion of spleen cells from the immunized mice with myeloma cells to create hybridoma cells. These hybridoma cells are then screened to identify those that produce the desired antibody .
The mouse anti-human KLF7 antibody is widely used in research to study the expression and function of KLF7 in various biological processes. It is commonly employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect KLF7 in tissue samples and cell cultures. By using this antibody, researchers can gain insights into the role of KLF7 in different physiological and pathological conditions, including its involvement in neurodevelopmental disorders like ASD .
