KIR2DL5A Human
Sf9, Baculovirus cells.
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A, Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail 5A, KIR2DL5, CD158F, Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5, Killer Cell Immunoglobulin-Like Receptor KIR2DL5A, Killer Cell Immunoglobulin-Like Receptor 2DL5A, CD158f1 Antigen, KIR2DL5.1, KIR2DL5.3, CD158F1, KIR2DL5A.
Greater than 90.0% as determined by SDS-PAGE.
Description
KIR2DL5A Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 459 amino acids (22-238a.a.) and having a molecular mass of 50.5kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). KIR2DL5A is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A, Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail 5A, KIR2DL5, CD158F, Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5, Killer Cell Immunoglobulin-Like Receptor KIR2DL5A, Killer Cell Immunoglobulin-Like Receptor 2DL5A, CD158f1 Antigen, KIR2DL5.1, KIR2DL5.3, CD158F1, KIR2DL5A.
Sf9, Baculovirus cells.
ADPHEGGQDK PLLSAWPSAV VPRGGHVTLL CRSRLGFTIF SLYKEDGVPV PELYNKIFWK SILMGPVTPA HAGTYRCRGS HPRSPIEWSA PSNPLVIVVT GLFGKPSLSA QPGPTVRTGE NVTLSCSSRS SFDMYHLSRE GRAHEPRLPA VPSVNGTFQA DFPLGPATHG GTYTCFGSLH DSPYEWSDPS DPLLVSVTGN SSSSSSSPTE PSSKTGIRRH VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH.
Product Science Overview
The KIR2DL5A protein is a type I transmembrane protein with a long cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) . These motifs are crucial for the inhibitory function of the receptor. The extracellular region of KIR2DL5A contains two immunoglobulin-like domains, which are responsible for binding to HLA class I molecules .
KIR2DL5A functions as an inhibitory receptor, meaning that upon binding to its ligand, it transmits inhibitory signals to the NK cell, preventing it from killing the target cell . This mechanism is essential for maintaining self-tolerance and preventing autoimmunity.
The KIR gene family is highly polymorphic, with significant variation in gene content and alleles among individuals . KIR2DL5A and its closely related gene, KIR2DL5B, are present in over half of the population . However, not all alleles of these genes are expressed, and alternative splicing can result in different isoforms of the protein .
KIR2DL5A is expressed in a subset of NK cells and some T cells, but its expression is not as ubiquitous as other KIRs . The promoter region of KIR2DL5A contains multiple binding sites for transcription factors that are expressed in hematopoietic cell lineages .
The study of KIR2DL5A and other KIRs is important for understanding the regulation of NK cell activity and its implications in various diseases. Variations in KIR genes have been associated with susceptibility to infections, autoimmune diseases, and cancer . Additionally, KIR2DL5A’s role in transplantation immunology is of particular interest, as mismatches in KIR-HLA interactions can affect transplant outcomes .
