KRT18 Bovine
Bovine liver.
Keratin type I cytoskeletal 18, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18,CYK18,Cell proliferation-inducing gene 46 protein.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 95.0% as determined by SDS-PAGE.
Description
KRT18 Bovine having a calculated molecular mass of 45 kDa, pI-5.4.
Product Specs
Keratin type I cytoskeletal 18, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18,CYK18,Cell proliferation-inducing gene 46 protein.
Bovine liver.
Product Science Overview
CK18 is a specific marker for bovine intestinal M cells, which are specialized epithelial cells found in the follicle-associated epithelium (FAE) of Peyer’s patches . These cells play a significant role in mucosal immune responses by transporting antigens from the lumen to immune cells. The expression of CK18 in these cells helps in identifying and studying their function and behavior.
In bovine intestinal cells, CK18 is expressed in the jejunal and ileal FAE regions. The expression patterns of CK18 are similar to the localization of M cells, which have irregular and sparse microvilli and pocket-like structures containing lymphocytes . This specific expression pattern makes CK18 a valuable marker for identifying M cells in bovine studies.
CK18-positive cells in the bovine intestine exhibit typical morphological characteristics of M cells, such as irregular microvilli and the presence of lymphocytes in pocket-like structures. In contrast, CK18-negative cells have regular and dense microvilli, typical of enterocytes .
Research on CK18 in bovine species has provided insights into the differentiation and function of intestinal epithelial cells. For example, studies have shown that CK18-positive M cells in the crypt continue to express CK18 as they move to the FAE region, while CK18-negative cells transition to CK20-positive enterocytes and undergo apoptosis at the apex of the FAE .
The specific expression of CK18 in bovine M cells has also been used to study the interactions between intestinal epithelial cells and pathogens, as well as the immune responses in the gut. This research has implications for understanding bovine health and developing strategies to improve immune responses in livestock.
