IL 13 Rhesus Macaque
Description
The IL 13 Rhesus Macaque is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Interleukin-13 (IL-13) is a cytokine that plays a crucial role in the immune system, particularly in the regulation of inflammatory responses. It is involved in various biological processes, including the modulation of immune cell activity, the promotion of allergic responses, and the regulation of tissue remodeling. Recombinant IL-13 from rhesus macaques (Macaca mulatta) is used in research to study these processes in a model that closely resembles human physiology.
Rhesus macaques are widely used in biomedical research due to their genetic, physiological, and immunological similarities to humans . These primates have been instrumental in the development of vaccines, the study of infectious diseases, and the understanding of immune responses. The use of recombinant proteins from rhesus macaques allows researchers to investigate the effects of these proteins in a controlled and reproducible manner.
IL-13 is produced primarily by T-helper type 2 (Th2) cells and is involved in the regulation of immune responses. It shares many functions with IL-4, including the promotion of B-cell proliferation and differentiation, the induction of class switch recombination to IgE, and the regulation of macrophage activity. IL-13 also plays a role in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis, by promoting the production of mucus and the recruitment of eosinophils to sites of inflammation .
Recombinant IL-13 is produced using genetic engineering techniques. The gene encoding IL-13 is cloned into an expression vector, which is then introduced into a host cell line, such as Escherichia coli or Chinese hamster ovary (CHO) cells. The host cells express the IL-13 protein, which is subsequently purified using chromatography techniques. The recombinant IL-13 can then be used in various experimental assays to study its biological effects .
Recombinant IL-13 from rhesus macaques is used in a variety of research applications, including:
- Immunology: Studying the role of IL-13 in immune cell signaling and function.
- Allergy and Asthma: Investigating the mechanisms underlying allergic responses and the development of asthma.
- Infectious Diseases: Exploring the role of IL-13 in the immune response to infections.
- Cancer Research: Examining the effects of IL-13 on tumor growth and the tumor microenvironment .
