IL5RA Human
Interleukin 5 Receptor Subunit Alpha, Interleukin 5 Receptor, Alpha, IL-5 Receptor Subunit Alpha, IL-5R Subunit Alpha, CD125 Antigen, CDw125, IL5R, Interleukin-5 Receptor Subunit Alpha, Interleukin-5 Receptor Alpha Chain, Interleukin 5 Receptor Type 3, IL-5R-Alpha, HSIL5R3, IL-5RA, CD125, Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA.
Greater than 95.0% as determined by SDS-PAGE.
Description
IL5RA produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 331 amino acids (21-342a.a.) and having a molecular mass of 37.8kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
IL5RA is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Interleukin 5 Receptor Subunit Alpha, Interleukin 5 Receptor, Alpha, IL-5 Receptor Subunit Alpha, IL-5R Subunit Alpha, CD125 Antigen, CDw125, IL5R, Interleukin-5 Receptor Subunit Alpha, Interleukin-5 Receptor Alpha Chain, Interleukin 5 Receptor Type 3, IL-5R-Alpha, HSIL5R3, IL-5RA, CD125, Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA.
ADPDLLPDEK ISLLPPVNFT IKVTGLAQVL LQWKPNPDQE QRNVNLEYQV KINAPKEDDY ETRITESKCV TILHKGFSAS VRTILQNDHS LLASSWASAE LHAPPGSPGT SIVNLTCTTN TTEDNYSRLR SYQVSLHCTW LVGTDAPEDT QYFLYYRYGS WTEECQEYSK DTLGRNIACW FPRTFILSKG RDWLAVLVNG SSKHSAIRPF DQLFALHAID QINPPLNVTA EIEGTRLSIQ WEKPVSAFPI HCFDYEVKIH NTRNGYLQIE KLMTNAFISI IDDLSKYDVQ VRAAVSSMCR EAGLWSEWSQ PIYVGNDEHK PLREWHHHHH H.
Product Science Overview
Interleukin-5 Receptor Alpha (IL-5Rα), also known as CD125, is a protein that plays a crucial role in the immune system, particularly in the regulation of eosinophils. Eosinophils are white blood cells that are involved in the body’s response to allergens and parasitic infections. The recombinant form of this receptor is used in various research and therapeutic applications.
IL-5Rα is a subunit of the IL-5 receptor, which is a heterodimer consisting of the alpha subunit (IL-5Rα) and the beta subunit (βc). The alpha subunit is responsible for binding to the IL-5 cytokine, while the beta subunit is shared with other cytokine receptors and is involved in signal transduction .
The IL-5 receptor is primarily expressed on the surface of eosinophils and basophils. Upon binding to IL-5, the receptor activates various intracellular signaling pathways, leading to the proliferation, differentiation, and survival of eosinophils .
Recombinant IL-5Rα is produced using recombinant DNA technology, where the gene encoding the human IL-5Rα protein is inserted into a suitable expression system, such as Chinese Hamster Ovary (CHO) cells. This allows for the large-scale production of the protein for research and therapeutic purposes .
The recombinant form of IL-5Rα is often used in studies to understand the receptor’s role in immune responses and to develop targeted therapies for conditions involving eosinophils, such as asthma and eosinophilic esophagitis .
- Research: Recombinant IL-5Rα is used in various research applications to study the signaling pathways and biological functions of the IL-5 receptor. It helps in understanding the mechanisms underlying eosinophil-related diseases and in identifying potential therapeutic targets .
- Therapeutics: The recombinant receptor is also used in the development of therapeutic agents. For example, monoclonal antibodies targeting IL-5Rα have been developed to treat eosinophilic disorders by blocking the interaction between IL-5 and its receptor .
