IL36G Mouse

Interleukin-36 gamma (IL-36γ), also known as IL-1F9, is a member of the interleukin-1 (IL-1) cytokine family. This family includes three closely related genes: IL-36α, IL-36β, and IL-36γ, which were formerly known as IL-1F6, IL-1F8, and IL-1F9, respectively . IL-36γ is a protein coding gene and plays a significant role in immune response and inflammation .

IL-36γ is synthesized as an inactive precursor that requires proteolytic processing at the N-terminus to become active . This activation is typically mediated by neutrophil granule-derived proteases, such as elastase and cathepsin G . The active form of IL-36γ binds to the IL-36 receptor (IL-36R), which then recruits the IL-1 receptor accessory protein (IL-1RAcP) to form a signaling complex . This complex activates downstream signaling pathways, including NF-κB and mitogen-activated protein kinases (MAPKs), leading to the production of pro-inflammatory mediators .

IL-36γ is predominantly expressed in epithelial tissues, including the skin, respiratory epithelium, and various nervous tissues . It is also expressed in monocytes and macrophages . The expression of IL-36γ is rapidly induced in response to inflammatory stimuli, such as tumor necrosis factor (TNF) or phorbol 12-myristate 13-acetate (PMA) .

The primary function of IL-36γ is to modulate immune responses and inflammation. It has been shown to activate T cell proliferation and the release of interleukin-2 (IL-2) . IL-36γ also plays a significant role in the pathogenesis of various inflammatory diseases, including psoriasis, psoriatic arthritis, systemic lupus erythematosus, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, and Sjögren’s syndrome .

IL-36γ has been linked to several inflammatory diseases, particularly those affecting the skin. In psoriasis, IL-36γ expression is significantly increased and contributes to the inflammatory response by enhancing the Th17/Th23 axis . Genetic mutations in the IL-36 receptor antagonist (IL-36Ra) are associated with generalized pustular psoriasis, a rare but life-threatening skin disease . Anti-IL-36 antibodies have been shown to attenuate skin inflammation in mouse models of psoriasis, highlighting the potential therapeutic value of targeting IL-36γ in inflammatory diseases .

Recombinant IL-36γ (Mouse) is produced using recombinant DNA technology, typically expressed in Escherichia coli . This recombinant protein is used in various research applications to study the function and signaling pathways of IL-36γ. It is also utilized in the development of potential therapeutic strategies for treating inflammatory diseases .