IL1F10 Human

Interleukin 1 Family, Member 10 (IL1F10), also known as Interleukin-38 (IL-38), is a cytokine belonging to the interleukin 1 family. This family of cytokines plays a crucial role in the regulation of immune and inflammatory responses. IL1F10 is encoded by the IL1F10 gene in humans and is expressed in various tissues, including the fetal skin, spleen, and tonsils .

IL1F10 is a protein consisting of 152 amino acids with a molecular mass of approximately 17 kDa . It is produced as a single, non-glycosylated polypeptide chain. The protein is expressed in the basal epithelia of the skin and in proliferating B-cells of the tonsils . The amino acid sequence of IL1F10 includes a signal peptide that directs the protein to be secreted outside the cell.

IL1F10 binds to the soluble IL1 receptor type 1 (IL1R1) and is implicated in the regulation of both adaptive and innate immune responses . It has been shown to modulate the activity of other cytokines and immune cells, thereby playing a role in controlling inflammation and immune responses. The exact mechanisms of IL1F10’s action are still under investigation, but it is believed to have anti-inflammatory properties.

Recombinant human IL1F10 is produced using various expression systems, including Escherichia coli (E. coli) and yeast . The recombinant protein is typically purified using chromatographic techniques to achieve high purity levels. The lyophilized (freeze-dried) form of IL1F10 is stable at room temperature for several weeks but should be stored at -18°C for long-term preservation .

Recombinant IL1F10 is used in research to study its role in immune regulation and inflammation. It is also utilized in the development of therapeutic strategies for diseases involving dysregulated immune responses, such as autoimmune diseases and inflammatory conditions . The protein’s ability to bind to IL1R1 makes it a valuable tool for investigating the signaling pathways mediated by the interleukin 1 family.