IL1F10 Human His

Interleukin 1 Family, Member 10 (IL1F10), also known as Interleukin-38, is a protein that belongs to the interleukin 1 cytokine family. This family of cytokines plays a crucial role in the regulation of immune and inflammatory responses. IL1F10 is particularly interesting due to its immunomodulatory properties and its potential therapeutic applications.

IL1F10 is a single, non-glycosylated polypeptide chain consisting of 172 amino acids. The human recombinant version of IL1F10 is produced in Escherichia coli (E. coli) and is fused to a 20 amino acid His-tag at the N-terminus. This His-tag facilitates the purification of the protein using chromatographic techniques .

IL1F10 is expressed in various tissues, including the fetal skin, spleen, and tonsil. Within these tissues, it is generally found in the basal epithelia of the skin and in the proliferating B-cells of the tonsil . This specific expression pattern suggests that IL1F10 may have specialized roles in skin and immune system development and function.

IL1F10 is known for its immunomodulatory activity. Unlike other cytokines, IL1F10 alone does not induce cytokine production. However, it has been shown to reduce the production of IL22 and IL17A, which are cytokines involved in inflammatory responses . This suggests that IL1F10 may play a role in dampening excessive immune responses, making it a potential candidate for therapeutic interventions in inflammatory and autoimmune diseases.

The IL1F10 gene is associated with several diseases, including Hypotrichosis 8 and Temporal Arteritis . Understanding the function and regulation of IL1F10 could provide insights into the pathogenesis of these diseases and aid in the development of targeted therapies.