IL19 Human, HEK
HEK293 cells.
Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19
Sterile filtered colorless solution.
Greater than 95.0% as determined by SDS-PAGE.
Description
IL19 Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (a.a 25-177) containing 164 amino acids and having a molecular mass of 19.1 kDa.
IL19 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19
HEK293 cells.
DGSHMLRRCL ISTDMHHIEE SFQEIKRAIQ AKDTFPNVTI LSTLETLQII KPLDVCCVTK NLLAFYVDRV FKDHQEPNPK ILRKISSIAN SFLYMQKTLR QCQEQRQCHC RQEATNATRV IHDNYDQLEV HAAAIKSLGE LDVFLAWINK NHEVMFSAHH HHHH
Product Science Overview
IL-19 is preferentially expressed in monocytes, macrophages, and T and B lymphocytes . It is produced by B cells and monocytes and binds to the interleukin 20 receptor complex to activate STAT3 signaling . The production of IL-19 is up-regulated in resting monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS) .
IL-19 plays a significant role in the immune response by promoting T helper 2 (Th2) cell-mediated immune responses . It induces the expression of IL-6 and tumor necrosis factor alpha (TNF-α) in monocytes . IL-19 initiates the JAK-STAT signaling pathway, which activates genes and creates mRNA sequences that are translated into proteins with downstream effector functions . The signaling involves the IL-20 dimer receptor complexes that bind the IL-19 ligand, Janus kinases (JAKs), and the signal transducer and activator of transcription 3 (STAT3) .
Recombinant IL-19 (Human Recombinant, HEK) is produced in HEK 293 cells. It is typically used in research settings to study its effects on immune responses and its potential therapeutic applications . The recombinant form of IL-19 is available in various purities and formulations, and it is often lyophilized from a sterile filtered solution containing trifluoroacetic acid (TFA) .
IL-19 has broad functions across inflammation, cell development, viral responses, and lipid metabolism . As an immunosuppressive cytokine, IL-19 promotes an anti-inflammatory lymphocyte phenotype, dampens the Th1 T-cell response, and increases IL-10 expression in peripheral blood mononuclear cells (PBMC) . It also inhibits the production of immunoglobulin G (IgG) from B cells .
