IL 19 Human
(b) Analysis by SDS-PAGE.
Description
The IL-19 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Interleukin-19 (IL-19) is a cytokine that belongs to the IL-10 family of related cytokines. It is primarily produced by monocytes and has been found to play a significant role in the regulation of immune responses. IL-19 is known for its involvement in enhancing chronic inflammatory diseases such as asthma .
The human IL-19 gene contains two alternate translation initiation sites, generating precursors of 215 amino acids (aa) and 177 aa, respectively. Both isoforms are processed to 17 kDa, 153 aa mature molecules . The recombinant form of IL-19 is typically produced in E. coli and is used in various research applications to study its effects on immune cells and inflammatory responses .
IL-19 is known to bind to the IL-20 receptor complex, leading to the activation of the signal transducer and activator of transcription 3 (STAT3) . This activation plays a crucial role in the regulation of immune responses, particularly in the lungs and airways. Studies have shown that IL-19 can enhance the expression of Major Histocompatibility Complex class II (MHCII) in alveolar macrophages and lung dendritic cells, which are essential for antigen presentation to T lymphocytes .
IL-19 has been reported to enhance chronic inflammatory diseases such as asthma. In vivo studies have shown that IL-19-deficient mice have a decreased percentage of CD11c+ cells in the bronchoalveolar lavage (BAL) due to the deficiency in IL-19 . Additionally, airway inflammation and histological changes in the lungs were ameliorated in IL-19-deficient mice challenged with Aspergillus antigen, which induces T lymphocyte-dependent allergic inflammation .
Recombinant human IL-19 protein is widely used in research to study its effects on immune cells and inflammatory responses. The recombinant protein is typically produced in E. coli and is available in both carrier-free and carrier-containing formulations . It is used in various assays, including cell proliferation assays, to study its biological activity and potential therapeutic applications .
