IL17RB Mouse

Interleukin-17 Receptor Beta Mouse Recombinant
Cat. No.
BT10353
Source
Sf9, Baculovirus cells.
Synonyms
Il17rb, Evi27, IL-17ER, IL-17Rh1, Il17br, IL17RH1, IL-17 receptor B, IL-17RB, Interleukin-17 receptor B.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

IL17RB produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 511 amino acids (18-286 a.a.) and having a molecular mass of 57.1kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa). IL17RB is expressed with an 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

Product Specs

Introduction
IL-17, also known as interleukin-17, is a pro-inflammatory cytokine primarily secreted by activated T helper 17 (Th17) cells. This cytokine plays a crucial role in regulating immune responses and inflammatory processes. IL-17 exerts its effects by binding to the IL-17 receptor (IL-17R), leading to the activation of downstream signaling pathways such as NF-κB and MAPK. These pathways contribute to the production of various pro-inflammatory mediators, including cytokines (e.g., IL-6), chemokines, and matrix metalloproteinases. Dysregulated IL-17 signaling has been implicated in the pathogenesis of multiple autoimmune and inflammatory diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis.
Description
IL17RB, also known as interleukin-17 receptor B, is a protein that plays a critical role in the immune system's response to inflammation. This recombinant IL17RB protein, produced in Sf9 insect cells using baculovirus expression system, is a single, glycosylated polypeptide chain comprising 511 amino acids. To facilitate purification and detection, it carries a 242 amino acid hIgG-His tag at its C-terminus. The protein exhibits a molecular weight of approximately 57.1 kDa, although it may appear as a band between 57-70 kDa on SDS-PAGE due to glycosylation. The purity of this IL17RB protein is greater than 90% as determined by SDS-PAGE analysis.
Physical Appearance
Clear, colorless solution that has been sterilized by filtration.
Formulation
This IL17RB protein solution is supplied at a concentration of 1 mg/mL in a buffer consisting of Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), keep the IL17RB protein solution refrigerated at 4°C. For extended storage, it is recommended to freeze the solution at -20°C. To ensure optimal stability during long-term storage, consider adding a carrier protein such as HSA or BSA to a final concentration of 0.1%. Avoid repeated freeze-thaw cycles to maintain protein integrity.
Purity
Greater than 90% pure as determined by SDS-PAGE analysis.
Synonyms
Il17rb, Evi27, IL-17ER, IL-17Rh1, Il17br, IL17RH1, IL-17 receptor B, IL-17RB, Interleukin-17 receptor B.
Source
Sf9, Baculovirus cells.
Amino Acid Sequence
ADPREPTIQC GSETGPSPEW MVQHTLTPGD LRDLQVELVK TSVAAEEFSI LMNISWILRA DASIRLLKAT KICVSGKNNM NSYSCVRCNY TEAFQSQTRP SGGKWTFSYV GFPVELSTLY LISAHNIPNA NMNEDSPSLS VNFTSPGCLN HVMKYKKQCT EAGSLWDPDI TACKKNEKMV EVNFTTNPLG NRYTILIQRD TTLGFSRVLE NKLMRTSVAI PVTEESEGAV VQLTPYLHTC GNDCIRREGT VVLCSETSAP IPPDDNRRML GGVEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H

Product Science Overview

Introduction

Interleukin-17 (IL-17) is a pro-inflammatory cytokine produced by activated T cells. It plays a crucial role in the immune response by regulating the activities of NF-kappaB and mitogen-activated protein kinases . The IL-17 family includes six cytokines (IL-17A to IL-17F), each with distinct roles in immune regulation .

IL-17 Receptor Family

The IL-17 receptor family consists of five members: IL-17RA, IL-17RB, IL-17RC, IL-17RD, and IL-17RE . These receptors share a common cytoplasmic motif known as the SEF/IL-17R (SEFIR) domain, which is essential for signal transduction .

Interleukin-17 Receptor Beta (IL-17RB)

IL-17RB, also known as IL-17 receptor B, is one of the receptors in the IL-17 family. It specifically binds to IL-17B and IL-17E (also known as IL-25) . IL-17RB is involved in various biological processes, including inflammation and immune response. It has been shown to stimulate the production of cytokines such as IL-6 and cyclooxygenase-2 (COX-2), as well as enhance the production of nitric oxide (NO) .

Recombinant IL-17RB (Mouse)

Recombinant IL-17RB (Mouse) is a bioengineered version of the IL-17RB protein derived from mouse cells. It is used in research to study the functions and signaling pathways of IL-17RB. This recombinant protein is produced using various expression systems, including E. coli and insect cells, to ensure its bioactivity and stability .

Role in Disease and Therapeutics

IL-17RB has been implicated in several diseases, including cancer and autoimmune disorders. In mouse models, IL-17B signaling through IL-17RB promotes cancer cell survival, proliferation, and migration, and induces resistance to conventional chemotherapeutic agents . This makes IL-17RB a potential therapeutic target for developing treatments for these diseases.

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