IL17RA Human
Sf9, Baculovirus cells.
Interleukin 17 Receptor A, IL-17 Receptor A, IL-17RA, CDw217, IL17R, Interleukin-17 Receptor A, Interleukin 17 Receptor, CD217 Antigen, HIL-17R, CANDF5, CD217, IMD51.
Greater than 90% as determined by SDS-PAGE.
Description
IL17RA Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 527 amino acids (33-320) and having a molecular mass of 60.4kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). IL17RA is fused to a 239 amino acids hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Interleukin 17 Receptor A, IL-17 Receptor A, IL-17RA, CDw217, IL17R, Interleukin-17 Receptor A, Interleukin 17 Receptor, CD217 Antigen, HIL-17R, CANDF5, CD217, IMD51.
Sf9, Baculovirus cells.
LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLWVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH.
Product Science Overview
Interleukin-17 Receptor Alpha (IL-17RA) is a critical component of the immune system, playing a pivotal role in mediating inflammatory responses. It is a receptor for the cytokine Interleukin-17 (IL-17), which is produced primarily by T cells. The IL-17 family consists of six cytokines (IL-17A to IL-17F), with IL-17A being the most studied due to its significant role in various infectious diseases, inflammatory and autoimmune disorders, and cancer .
IL-17A was first discovered in 1993 and was initially termed cytotoxic T lymphocyte antigen 8 (CTLA-8). The IL-17-binding receptor, IL-17RA, was identified in 1995 . IL-17RA is ubiquitously expressed, making nearly all cells potential targets for IL-17. The receptor is characterized by a shared cytoplasmic motif named the SEF/IL-17R (SEFIR), which is crucial for signal transduction .
IL-17RA is involved in various biological functions, primarily through its interaction with IL-17A. This interaction leads to the activation of several signaling pathways that result in the production of proinflammatory cytokines, chemokines, and other mediators. These molecules play essential roles in recruiting neutrophils and other immune cells to sites of infection or injury, thereby contributing to the body’s defense mechanisms .
The IL-17/IL-17RA axis has been implicated in several pathological conditions. For instance, IL-17A is recognized as a hallmark molecule of CD4+ T helper 17 (Th17) cells, which are involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis and psoriasis . Additionally, IL-17A and its receptor have been identified as potential therapeutic targets in sepsis, a severe and often fatal systemic inflammatory response to infection .
Recombinant IL-17RA is a laboratory-produced version of the natural receptor, designed for research and therapeutic purposes. It is used to study the receptor’s structure, function, and interactions with IL-17A and other cytokines. Recombinant IL-17RA can also be employed in drug development to screen for potential inhibitors that could modulate the IL-17/IL-17RA signaling pathway, offering new avenues for treating inflammatory and autoimmune diseases .
