IL13RA2 Human
Interleukin 13 Receptor, Alpha 2 Human Recombinant
Cat. No.
BT8880
Source
Escherichia Coli.
Synonyms
CD213A2, CT19, IL-13R, IL13BP, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, CD_antigen=CD213a2, Interleukin-13-binding protein.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
IL13RA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 340 amino acids (27-343 a.a.) and having a molecular mass of 39.5kDa.
IL13RA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
IL13RA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Interleukin 13 Receptor, Alpha 2 (IL13RA2) belongs to the type I cytokine receptor family and specifically to the Type 5 subfamily. It shares similarities with IL13RA1, a component of the interleukin 13 receptor complex. IL13RA2 exhibits high-affinity binding to IL13. However, due to the absence of a cytoplasmic domain, it is not believed to function as a signal transducer. Instead, IL13RA2 is thought to participate in the internalization of IL13.
Description
Recombinant human IL13RA2, expressed in E. coli, is a single polypeptide chain lacking glycosylation. It encompasses 340 amino acids (residues 27-343) and has a molecular weight of 39.5 kDa. This protein includes a 23 amino acid His-tag at the N-terminus. Purification is achieved using proprietary chromatographic techniques.
Physical Appearance
The product is a clear solution that has been sterilized by filtration.
Formulation
The IL13RA2 protein solution is provided at a concentration of 1 mg/ml. The solution contains 20 mM Tris-HCl buffer (pH 8.0), 0.4 M urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to store the product frozen at -20°C. To ensure optimal stability during long-term storage, the addition of a carrier protein (0.1% HSA or BSA) is advised. Avoid subjecting the product to repeated cycles of freezing and thawing.
Purity
Analysis by SDS-PAGE indicates a purity exceeding 85.0%.
Synonyms
CD213A2, CT19, IL-13R, IL13BP, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, CD_antigen=CD213a2, Interleukin-13-binding protein.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSDTEIKVN PPQDFEIVDP GYLGYLYLQW QPPLSLDHFK ECTVEYELKY RNIGSETWKT IITKNLHYKD GFDLNKGIEA KIHTLLPWQC TNGSEVQSSW AETTYWISPQ GIPETKVQDM DCVYYNWQYL LCSWKPGIGV LLDTNYNLFY WYEGLDHALQ CVDYIKADGQ NIGCRFPYLE ASDYKDFYIC VNGSSENKPI RSSYFTFQLQ NIVKPLPPVY LTFTRESSCE IKLKWSIPLG PIPARCFDYE IEIREDDTTL VTATVENETY TLKTTNETRQ LCFVVRSKVN IYCSDDGIWS EWSDKQCWEG EDLSKKTLLR.
Product Science Overview
Introduction
Structure and Function
IL-13Rα2 binds interleukin-13 (IL-13) with high affinity but lacks a significant cytoplasmic domain, which means it does not function as a signal mediator . Despite this, IL-13Rα2 plays a crucial role in regulating the effects of both IL-13 and interleukin-4 (IL-4), although it cannot bind directly to IL-4 . It is also involved in the internalization of IL-13, which is essential for modulating immune responses .
Expression and Localization
Clinical Significance
Recombinant IL-13Rα2
Recombinant IL-13Rα2 is produced using recombinant DNA technology, which involves inserting the IL13RA2 gene into a suitable expression system to produce the protein in large quantities . This recombinant protein is used in research to study its role in immune regulation and its potential as a therapeutic target in cancer treatment .
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