HTLV-1 p24 core
Description
The protein contains 214 amino acids having an Mw of 24kDa.
Product Specs
Product Science Overview
Human T-cell leukemia virus type 1 (HTLV-1) is a deltaretrovirus that primarily infects T-lymphocytes, specifically CD4+ and CD8+ T-cells. This virus is associated with several diseases, including adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The p24 core protein is a major structural component of the HTLV-1 virus, playing a crucial role in the formation of the viral capsid.
The p24 core protein is encoded by the gag gene of HTLV-1. It forms the conical core of the virus, encapsulating the genomic RNA-nucleocapsid complex. This protein is essential for the assembly and maturation of the virus, making it a key target for diagnostic and therapeutic applications.
Recombinant HTLV-1 p24 core protein is produced using recombinant DNA technology, typically in Escherichia coli (E. coli) expression systems. The recombinant protein contains the full-length sequence of the HTLV-1 p24 core protein and is purified using proprietary chromatographic techniques to achieve high purity levels (greater than 95%) .
The recombinant HTLV-1 p24 core protein is widely used in various research and diagnostic applications:
- Antigen in ELISA and Western Blots: It serves as an excellent antigen for the early detection of HTLV-1 infections, showing minimal specificity problems.
- Immunohistochemistry: It is used for the immunohistochemical localization of HTLV-1 p24-related antigens in tissue samples.
- Vaccine Development: The protein is also explored as a potential component in vaccine formulations against HTLV-1.
Several studies have highlighted the importance of the HTLV-1 p24 core protein in understanding the pathogenesis of HTLV-1 and developing diagnostic tools:
- Monoclonal Antibody-Based Detection: Development of monoclonal antibody-based assays for detecting HTLV-1 p24 antigen in infected individuals .
- Localization in Tissues: Immunohistochemical studies have localized HTLV-1 p24 antigens in synovial joints of patients with rheumatoid arthritis, suggesting a possible link between HTLV-1 infection and autoimmune diseases .
- Immune Response: Research has shown that the HTLV-1 p24 core protein can elicit strong immune responses, making it a valuable tool for studying the immune mechanisms involved in HTLV-1 infections .
