HTLV-1 p24
HTLV-1 p24 Recombinant
Cat. No.
BT25028
Source
Escherichia Coli.
Synonyms
Appearance
Sterile Filtered clear solution.
Purity
Protein is >95% pure as determined by 12% SDS-PAGE (coomassie staining).
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
HTLV-1 p24 Recombinant produced in E.Coli covers full length of HTLV-1 p24 and contains 188 amino acids having a molecular size 21kDa.
HTLV-1 p24 is purified by proprietary chromatographic technique.
HTLV-1 p24 is purified by proprietary chromatographic technique.
Product Specs
Introduction
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cells called Th1 cells. This activation leads to the proliferation of Th1 cells and an overproduction of Th1-related cytokines, primarily IFN-gamma and TNF-alpha. Consequently, feedback mechanisms from these cytokines suppress Th2 lymphocytes and reduce Th2 cytokine production, including IL-4, IL-5, IL-10, and IL-13. This imbalance ultimately impairs the infected host's ability to mount an adequate immune response against invading organisms that depend on a predominantly Th2 response. Such responses are crucial for combating parasitic infections and producing mucosal and humoral antibodies. HTLV-1 p24, often used for clinical diagnosis, forms both monomers and dimers on SDS-PAGE gels, with the majority existing as dimers.
Description
Recombinantly produced in E. coli, HTLV-1 p24 encompasses the full length of the HTLV-1 p24 protein. It consists of 188 amino acids, resulting in a molecular size of 21 kDa. The purification process for HTLV-1 p24 involves a proprietary chromatographic technique.
Physical Appearance
Sterile Filtered clear solution.
Formulation
HTLV-1 p24 protein solution in PBS, pH 7.4.
Stability
For optimal storage, HTLV-1 p24 should be kept below -18°C. While it remains stable at 4°C for up to one week, repeated freeze-thaw cycles should be avoided.
Purity
Protein purity is greater than 95%, as determined by 12% SDS-PAGE analysis with Coomassie staining.
Source
Escherichia Coli.
Product Science Overview
Structure and Function of HTLV-1 p24
Recombinant HTLV-1 p24
Applications
Recombinant HTLV-1 p24 is widely used in research and diagnostic applications. It serves as an antigen in enzyme-linked immunosorbent assays (ELISA) and Western blots, making it an excellent tool for the early detection of HTLV-1 infections . Additionally, it is used in studies to understand the immune response to HTLV-1 and to develop potential therapeutic interventions .
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