HSD17B8 Human
E2 17-beta-dehydrogenase 8, 17-beta-hydroxysteroid dehydrogenase 8, 17-beta-HSD 8, 3-oxoacyl-[acyl-carrier-protein] reductase, Protein Ke6, Ke-6, Really interesting new gene 2 protein, Testosterone 17-beta-dehydrogenase 8, HSD17B8, FABGL, HKE6, RING2, KE6, FABG, H2-KE6, SDR30C1, D6S2245E, dJ1033B10.9.
Description
HSD17B8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
E2 17-beta-dehydrogenase 8, 17-beta-hydroxysteroid dehydrogenase 8, 17-beta-HSD 8, 3-oxoacyl-[acyl-carrier-protein] reductase, Protein Ke6, Ke-6, Really interesting new gene 2 protein, Testosterone 17-beta-dehydrogenase 8, HSD17B8, FABGL, HKE6, RING2, KE6, FABG, H2-KE6, SDR30C1, D6S2245E, dJ1033B10.9.
Product Science Overview
The HSD17B8 gene is located on chromosome 6 and encodes a protein that is approximately 261 amino acids in length . The protein structure includes a conserved NAD(P)-binding domain, which is characteristic of the SDR family . This domain is essential for the enzyme’s catalytic activity, allowing it to participate in redox reactions involving steroid hormones .
HSD17B8 primarily functions as an oxidative enzyme, inactivating potent steroid hormones such as estradiol, testosterone, and dihydrotestosterone by converting them into their less active forms . Specifically, it catalyzes the conversion of estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to androstanedione . Although its primary role is oxidative, HSD17B8 also exhibits some reductive activity, enabling it to convert estrone back to estradiol under certain conditions .
The regulation of steroid hormone levels by HSD17B8 is vital for maintaining hormonal balance and ensuring proper physiological function. In particular, the enzyme’s activity is crucial in tissues where precise control of estrogen and androgen levels is necessary, such as the ovaries, testes, liver, pancreas, and kidneys . Dysregulation of HSD17B8 activity can lead to hormonal imbalances and has been associated with various diseases, including certain types of cancer .
Mutations or alterations in the HSD17B8 gene can have significant clinical implications. For instance, changes in the enzyme’s activity have been linked to conditions such as Fallopian Tube Serous Papilloma . Understanding the function and regulation of HSD17B8 is therefore important for developing therapeutic strategies for diseases related to steroid hormone imbalances.
Recombinant HSD17B8 refers to the enzyme produced through recombinant DNA technology, which involves inserting the HSD17B8 gene into a suitable expression system, such as bacteria or yeast, to produce the enzyme in large quantities. This recombinant form is used in research to study the enzyme’s structure, function, and potential therapeutic applications. It allows scientists to investigate the enzyme’s role in steroid metabolism and its impact on various physiological processes.
