HSD17B11 Human

The HSD17B11 gene is located on chromosome 4 and is responsible for encoding the HSD17B11 protein . This protein is widely expressed in various tissues, including the retina, pancreas, kidney, liver, lung, adrenal glands, small intestine, ovary, and heart . The enzyme’s activity is particularly significant in steroidogenic cells, where it participates in androgen metabolism during steroidogenesis .

HSD17B11 is involved in the metabolism of secondary alcohols and ketones . It has been shown to convert 5α-androstane-3α, 17β-diol to androsterone, suggesting its role in androgen metabolism . The enzyme’s activity is crucial for regulating the availability of steroids within various tissues throughout the body . It may act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it .

HSD17B11 has been identified as a tumor-associated antigen in cutaneous T-cell lymphoma . This association highlights its potential role in cancer biology and its importance as a target for therapeutic interventions. Additionally, the enzyme’s involvement in steroid metabolism suggests its relevance in conditions related to steroid hormone imbalances.

Recombinant HSD17B11 is produced using recombinant DNA technology, which allows for the expression of the human HSD17B11 protein in various host systems. This recombinant protein is used in research to study the enzyme’s function, mechanism, and potential therapeutic applications .