HRASLS3 Human

HRASLS3 is a single, non-glycosylated polypeptide chain consisting of 133 amino acids, with a molecular mass of approximately 14.9 kDa . The recombinant form of this protein is typically produced in Escherichia coli (E. coli) and is purified using proprietary chromatographic techniques .

HRASLS3 belongs to the class II tumor suppressor gene family and is involved in the regulation of cell differentiation and survival . It is known to participate in interferon-dependent cell death, which is a critical mechanism for controlling tumor growth and progression . The protein is expressed in various human tumors, including ovarian and lung carcinomas .

The exact molecular mechanisms by which HRASLS3 exerts its tumor-suppressive effects are still under investigation. However, it is believed to be involved in the regulation of lipid metabolism due to its phospholipase A2 activity . This activity allows HRASLS3 to hydrolyze phospholipids, which can influence membrane dynamics and signaling pathways critical for cell survival and proliferation .

Given its role in tumor suppression, HRASLS3 is a protein of interest in cancer research. Its expression patterns and functional mechanisms are being studied to develop potential therapeutic strategies for cancers where HRASLS3 is implicated . Additionally, the recombinant form of HRASLS3 is used in various research applications to further understand its biological functions and potential clinical applications .

For research purposes, HRASLS3 is typically stored at 4°C for short-term use and at -20°C for long-term storage. It is recommended to avoid multiple freeze-thaw cycles to maintain protein stability .