HIV-1 gp120 (PNDmn) antibody

Human Immunodeficiency Virus type 1 (HIV-1) is the virus responsible for causing Acquired Immunodeficiency Syndrome (AIDS). One of the key components of HIV-1 is the envelope glycoprotein gp120, which plays a crucial role in the virus’s ability to infect host cells. The gp120 protein is a surface glycoprotein that facilitates the virus’s entry into target cells by binding to the CD4 receptor and a co-receptor, either CCR5 or CXCR4, on the host cell surface .

The gp120 protein is part of the HIV-1 envelope glycoprotein complex, which also includes gp41. The gp120 protein is responsible for the initial attachment of the virus to the host cell. It undergoes significant conformational changes upon binding to the CD4 receptor, which then allows it to interact with the co-receptor. This interaction is critical for the fusion of the viral and host cell membranes, a process mediated by the gp41 protein .

The HIV-1 gp120 (PNDmn) mouse antibody is a monoclonal antibody that specifically targets the gp120 protein of HIV-1. This antibody is produced by immunizing mice with a recombinant form of the gp120 protein from the MN strain of HIV-1, which is a CCR5 and X4 tropic strain. The antibody is of the IgG1 isotype and is typically used in various research applications, including enzyme-linked immunosorbent assay (ELISA), Western blotting, and immunohistochemistry .

The HIV-1 gp120 (PNDmn) mouse antibody is a valuable tool in HIV research. It is used to study the structure and function of the gp120 protein, as well as to investigate the mechanisms of HIV-1 entry into host cells. Additionally, this antibody can be used to screen for potential inhibitors of the gp120-CD4 interaction, which is a critical step in the development of new therapeutic strategies against HIV-1 .